Postdoctoral Fellow - Bioinformatics, Computational Biology

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Name of Hiring Official/Investigator

Job Description

A computationally strong candidate is required for a postdoctoral project at the Frederick National Laboratory for Cancer Research to investigate the connections between adult cancers, pediatric tumors, and neurodevelopmental disorders by analyzing multi-omics datasets, including bulk, single-cell, and spatial-omics sequencing datasets. The focus will be on mutations and the alterations in cellular signaling pathways to find out how overlapping molecular features bring about these phenotypically very different pathologies, and critically, the consequent potential implications in drug treatment decisions. The connection between cancer, neurodevelopmental disorders, and pediatric tumors- at the molecular level- is an innovative, emerging area which has been pioneered by our group. In addition, mutational markers in metastasis will also be explored.

Experience and proficiency in high-throughput data analysis by using bioinformatics, machine learning and mathematical modeling are required. A good grasp of signaling pathways and biological network analysis tools, are pivotal too.

A record of publications with first authorship papers in reputable journals is required.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Training Position (Starting stipend: $65,100, bonuses may apply)
Work Schedule
Full-time (In-Person)
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills
  • Strong programming skills for handling and analyzing high-throughput multi-omics data with Python, R, Unix shell programming languages
  • Strong background in statistical modeling and AI-models
  • Experience in working with biological databases and data analysis tools
  • Excellent communication and teamwork skills
  • Good grasp of molecular biology of diseases and biological pathways (or interest in learning biological background)
  • Strong knowledge in protein-protein interaction networks
  • Experience with network visualization tools (e.g., Cytoscape)

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply
  • CV/Resume
  • Statement of Research Goals
  • 3 References
  • Cover Letter
  • Summary of Research Experience
Additional Application Information

For more information see Website:

To apply: please send CV and three names of references to Dr. Ruth Nussinov ( 

Contact Information
Contact Name
Ruth Nussinov
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.