A post doc position is available in the Surgical Oncology Program, CCR, NCI in Bethesda, Maryland. Our research aims to understand the mechanism involved in thyroid cancer progression and metastasis, and to identify the molecular pathways underlying resistance to targeted therapies. We apply multiple genomics and high-throughput screening to identify novel genetic vulnerabilities in metastatic thyroid cancer to overcome resistance to targeted therapies.
The Research Project
Progressive and metastatic cancer accounts for the majority of cancer-related morbidity and mortality. The understanding of the key regulators of cancer progression and metastasis has improved, but why certain therapies lack durable efficacy in advanced cancers is unknown. Thyroid cancer, a relatively common cancer, is an excellent model for studying cancer progression, because mutually exclusive driver mutations, such as BRAF V600E, coupled with additional alterations lead to more aggressive behavior, cancer cell dedifferentiation, resistance to therapy and metastasis.
In the current project, we will explore and identify determinants for synthetic lethality with targeted therapy utilizing a CRISPR screen approach. The successful candidates will utilize molecular and cellular biology in addition to bioinformatics and in vivo studies.
Qualifications and Job Details
Required and Preferred Skills
Qualified candidates should have a Ph.D. in a biological science or the equivalent with less than two years of post-doctoral experience. A background in molecular and cellular biology is required.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.