Our group studies the role of ABC drug transporters in the development of multidrug resistance in cancer cells. We use Biochemical, molecular biological, pharmacological, and molecular modeling approaches to understand the transport mechanism and underlying structural changes of ABC transporters, particularly ABCB1 and ABCG2 (see research article: https://www.pnas.org/doi/10.1073/pnas.2016270117). The Postbac will learn various cell biology and biochemical techniques including human cell culture, Western blotting, enzyme kinetics, and flow cytometry. The research experience at NCI/NIH would provide an opportunity for the Postbac to participate in cutting edge laboratory work, which will be useful for her/his future career in science.
Qualifications and Job Details
Required and Preferred Skills
Applicants must have an undergraduate degree in chemistry, biology, or biophysics and an interest in the structure and function analysis of membrane transport proteins.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.
This position is available from April 1, 2024. Applicant must be a US citizen or permanent resident.
Address: Transport Biochemistry Section, Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Drive, Room 2120, Bethesda, MD 20892-4256