Post-doctoral Fellow - T cell immunology, tumor immunology

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Job Description

A postdoctoral position is available in the Bosselut lab within the Laboratory of Immune Cell Biology, National Cancer Institute, to study T cell differentiation and function.

Potential research areas include CD4+ T cell exhaustion-dysfunction in tumors and chronic infection, differentiation and function of memory and follicular helper CD4+ T cells, and T cell development in the thymus. Research projects will be determined based on the applicant’s interests.

Research in the lab leverages highly innovative experimental approaches, including single-cell and tissue transcriptomics, single-cell epigenomics, and CRISPR-mediated genome editing, to explore infection and experimental tumor models.

Relevant recent publications, first-authored by lab members:

Ciucci, T. et al. (2019) The Emergence and Functional Fitness of Memory CD4(+) T Cells Require the Transcription Factor Thpok. Immunity 50, 91-105.e104. 10.1016/j.immuni.2018.12.019

Magen, A. et al. (2019) Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4(+) T Cells. Cell Rep 29, 3019-3032.e3016. 10.1016/j.celrep.2019.10.131

Vacchio, M.S. et al. (2019) A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation. Immunity 51, 465-478.e466. 10.1016/j.immuni.2019.06.023

Chopp, L.B. et al. (2020) An Integrated Epigenomic and Transcriptomic Map of Mouse and Human alphabeta T Cell Development. Immunity 53, 1182-1201 e1188. 10.1016/j.immuni.2020.10.024

Ciucci, T. et al. (2022) Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells. J Exp Med 219. 10.1084/jem.20202343

Nie, J. et al. (2022) The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα(+) intraepithelial lymphocyte precursors. Nat Immunol 23, 594-604. 10.1038/s41590-022-01161-x

Gao, Y. et al. (2022) NuRD complex recruitment to Thpok mediates CD4(+) T cell lineage differentiation. Sci Immunol 7, eabn5917. 10.1126/sciimmunol.abn5917

More information can be found at

The laboratory is located on the main NIH campus in Bethesda. We have access to exceptional research and support facilities, including flow cytometry, imaging, deep sequencing, mouse mutagenesis (transgenesis, homologous recombination and CRISPR genome editing), and we have collaborations and regular meetings with multiple NIH and academic groups, including computational biologists and bioinformaticians.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
M.D. or equivalent
Job Location
Appointment Type
Training Position (Stipend commensurate with experience)
Work Schedule
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

Ph.D.-level experience in immunology, molecular or cellular biology, genetics, tumor biology, or similar field.

Applicants should have (or be within a few months of obtaining) an M.D., or a Ph.D. in immunology, biochemistry, genetics or a similar field, with no more than 5 years of post-doctoral experience.

Preferred Skills

Candidates associating a strong publication record with experience in flow cytometry, bioinformatics, or gene expression analyses will be given priority review. Candidates with expertise or interest in bioinformatics are especially encouraged to apply to take advantage of collaborative possibilities on the NIH campus.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
  • CV/Resume
  • 3 References
  • Cover Letter
  • Summary of Research Experience
Contact Information
Contact Name
Remy Bosselut
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.