Successful postdoctoral candidates will develop new computational tools and experimental methodologies (e.g., spectral cytometry) to map out the systemic immune responses against cancers.
About our research: Recent progress in cancer immunotherapy has emphasized how multifactorial and systemic immune responses must be to trigger tumor eradication. The need for quantitative and actionable models is being acutely felt to expand our fundamental understanding of the immune system, and to usher new immunotherapies. The Altan-Bonnet group is studying the interplay between innate and adaptive immune responses across the whole organism. We aim to identify key immunoregulatory events distinguishing tumor progression versus eradication. We rely on mass cytometry (so-called spectral cytometry) and quantitative modeling to systematically map out the homeostasis and dynamics of immune activation across multiple cell types. To do so, we study mouse models of cancer development, and are translating our mouse-derived understanding to the analysis of clinical samples. Our ultimate goal is to develop quantitative models of interactions between immune and cancer cells to tackle their complex interactions, and to predict how to tweak the immune responses best.
Qualifications and Job Details
Required and Preferred Skills
- Quantitative skills (quantitative experimental skills and/or bioinformatics and/or theoretical modeling and/or engineering)
- Cellular immunology
- Programming skills (Python preferred or R/C)
- Single-cell analysis (scRNAseq and/or spectral cytometry)
- Cell culturing
- Robotics (e.g., TECAN EVO)
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
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