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Post-doctoral Fellow - Structural biology, chromatin structure

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Name of Hiring Official/Investigator

Job Description

The Protein and Chromatin Folding Section, Laboratory of Biochemistry and Molecular Biology, CCR, NCI, NIH is recruiting a postdoctoral fellow. Candidates with an interest in chromatin structure and its relationship to cancer are encouraged to apply.

The DNA molecules in eukaryotic cells are associated with histone proteins to form chromatin that can fold to various structures for the purpose of biological functions. The folding of chromatin is regulated by many other non-histone protein factors. We study chromatin folding through determination of the structures and dynamics of chromatin units and their complexes with regulatory proteins using single particle cryo-EM, X-ray crystallography, solution NMR, and other biophysical/biochemical methods. Our most recent studies include the high-resolution structural determination of chromatosomes with different linker histone isoforms, centromeric nucleosomes bound to kinetochore proteins, and nucleosomes with native DNA sequences and how they are recognized by pioneer transcription factors.

Interested candidates must have a Ph.D. with less than five years of relevant postdoctoral experience. Salary is commensurate with experience and accomplishments.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Bethesda
Appointment Type
Training Position (Stipend commensurate with experience)
Work Schedule
Full-time
Citizenship
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

Training in structural biology, biophysics, biochemistry or molecular biology is required.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Bethesda

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
Submit:
  • CV/Resume
  • 3 References
  • Cover Letter
Additional Application Information
Contact Information
Contact Name
Yawen Bai, Ph.D.
E-mail Address
baiyaw@mail.nih.gov
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.