The Protein and Chromatin Folding Section, Laboratory of Biochemistry and Molecular Biology, CCR, NCI, NIH is recruiting a postdoctoral fellow. Candidates with an interest in chromatin structure and its relationship to cancer are encouraged to apply.
The DNA molecules in eukaryotic cells are associated with histone proteins to form chromatin that can fold to various structures for the purpose of biological functions. The folding of chromatin is regulated by many other non-histone protein factors. We study chromatin folding through determination of the structures and dynamics of chromatin units and their complexes with regulatory proteins using single particle cryo-EM, X-ray crystallography, solution NMR, and other biophysical/biochemical methods. Our most recent studies include the high-resolution structural determination of chromatosomes with different linker histone isoforms, centromeric nucleosomes bound to kinetochore proteins, and nucleosomes with native DNA sequences and how they are recognized by pioneer transcription factors.
Interested candidates must have a Ph.D. with less than five years of relevant postdoctoral experience. Salary is commensurate with experience and accomplishments.
Qualifications and Job Details
Required and Preferred Skills
Training in structural biology, biophysics, biochemistry or molecular biology is required.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
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