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Post-doctoral Fellow - Osteosarcoma, metastasis

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Job Description

The NCI/CCR/Comparative Oncology Program is seeking highly motivated and collaborative candidates with a background in molecular biology and/or comparative oncology to use a multiprong experimental approach, including in vitro and in vivo modeling. The successful candidate will support studies in metastatic osteosarcoma (OS) initiated under the umbrella of the DOG2 project (Deciphering the Osteosarcoma Genome of the Dog). DOG2 is a multi-omic approach which leverages our access to high-quality clinically-annotated canine OS specimens collected during the last 4 years of clinical trial activities in >400 dogs with OS. Taking advantage of these invaluable tissue resources, current projects include: 1) a NanoString examination of primary:metastatic pairs using the Canine IO panel, 2) investigation of cellular senescence and the senescence-associated secretory phenotype (SASP) in osteosarcoma metastasis and in pulmonary fibrosis, and 3) an examination of the roles of the non-tumor tissue adjacent to osteosarcoma metastases. In addition, any identified druggable targets will be examined in preclinical (mouse) models to prioritize the best agents to carry forward into pet dog clinical trials, conducted through our extramural clinical trials consortium, the Comparative Oncology Trials Consortium (COTC).

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
M.D. or equivalent
Other: D.V.M.
Job Location
Bethesda
Appointment Type
Training Position (Stipend commensurate with experience)
Work Schedule
Full-time
Citizenship
US Citizenship required

Required and Preferred Skills

Required Skills

Ph.D., M.D., D.V.M. or equivalent; background in molecular biology and/or comparative oncology

Preferred Skills

Preference given to applicants with experience in molecular/cell biology, immunology or experimental pathology.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Bethesda

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
Submit:
  • CV/Resume
  • Statement of Research Goals
  • 3 References
  • Cover Letter
  • Summary of Research Experience
Contact Information
Contact Name
Amy LeBlanc
E-mail Address
amy.leblanc@nih.gov
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.