We seek to understand how HIV and other retroviruses interact with host factors to carry out key essential steps to form a transcriptionally active provirus, which include reverse transcription, nuclear import, uncoating, and integration. We are using state-of-the-art live-cell imaging combined with molecular biology and next-generation sequencing to gain new insights into the mechanism and dynamics of viral core nuclear import, location and timing of viral core uncoating, and integration site selection. We are using multi-disciplinary approaches to identify and characterize essential molecular interactions between viral and host proteins with the goal of developing new antiviral strategies. Further details and a list of publications can be found at https://ccr.cancer.gov/staff-directory/vinay-k-pathak.
Qualifications and Job Details
Required and Preferred Skills
A postdoctoral position is available in the Viral Mutation Section (VMS), HIV Dynamics and Replication Program (HIV DRP), Center for Cancer Research (CCR) to perform basic research on HIV replication post-entry events, including nuclear import, nuclear uncoating, integration, and latency and to develop novel antiviral strategies.
Applicants must have a strong background in molecular virology and/or molecular biology and biochemistry.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.
Starting stipend: $62,600, bonuses may apply. This is a time-limited, renewable appointment.