A post-doctoral fellow position is available in the Thoracic Surgery Branch, CCR, NCI, NIH.
Our broad goal is to explore the molecular and cellular biology of thoracic cancers, namely mesothelioma and/or, thymoma, non-small cell lung carcinoma, etc. Currently, we have projects that involve (1) investigating microRNA-mRNA interactions in malignant mesothelioma, (2) novel local therapeutic delivery system(s) able to carry diverse types of payloads including nucleic acid, immunotherapeutics, targeted small molecule agents, or antibodies, (3) on the pathogenic signaling pathways relevant to tumor initiation, invasion, metastasis, and resistance, (4) constructing next-generation models of normal cells/tissues that can be used to model tumor development and processes as well as several other translational-based endeavors (e.g., developing novel tumor diagnostics and prognostics, etc.). With these projects, we have aims of developing novel molecular biomarkers and therapeutic targets based on an understanding of the pathogenetic mechanisms active in these cancers. The culmination of these projects will be linked to clinical human protocols in these thoracic cancers of interest.
This is a great opportunity for candidates who are interested in cancer biology and want to enhance their career potential by working in our research program with the outstanding support of other established laboratories and core facilities in the NCI. This laboratory effort will be in close collaboration with other faculty in our branch, within the NIH community at large and/or extramural collaborators.
Qualifications and Job Details
Required and Preferred Skills
We highly value a team-based approach. Individuals with self-motivation and willingness to collaborate will be most successful in this environment. Qualified candidates should have a Ph.D. in a biological science area or the equivalent background (M.D., M.B.B.S., etc.) with one to five years of post-doctoral experience. A background and working knowledge in molecular or cellular biology, immunology, cancer or stem cell biology, or virology is required. Familiarity with basic techniques including DNA/RNA isolation, cell culture techniques, western blot, quantitative PCR, immunohistochemistry, ChIP, retroviral or lentiviral transfections, FACS sorting, CRISPR, and working with mice is a must. Knowledge and/or experience in bioinformatics, biostatistics, mutation detection, microarray analysis, RNA-seq and other sequencing (e.g., single cell-seq) methodology, and microRNA is preferred. Diverse backgrounds from biomedical engineering, materials science, or pharmacology would be advantageous.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
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