Osteosarcoma and other sarcomas are resistant to immunotherapies because they are generally “cold” tumors. Our recent studies have identified a surface protein that regulates osteosarcoma cell-host interaction. Preliminary data show that genetic deletion of this protein in osteosarcoma cells enhances infiltration of anti-tumor immune cells in the tumor and subsequent tumor reduction. However, the underlying mechanism is unknown. The successful candidate will investigate the mechanism using single-cell sequencing and high-throughput flow cytometry at the Laboratory of Cancer Biology and Genetics, NCI, NIH (Bethesda campus). The overarching goal is to identify new strategies to increase the efficacy of immunotherapy in osteosarcoma and other sarcomas.
Qualifications and Job Details
Required and Preferred Skills
Requirements include a strong background in cell biology, tumor biology, and immunology. Good communication skills are necessary.
Experiences in immunology, tumor (particularly sarcomas), and/or mouse models are a plus.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.