Post-doctoral Fellow - DNA topology, chromatin structure

Date Posted
Position is with
Name of Hiring Official/Investigator

Job Description

A postdoctoral fellow position is available in the laboratory of Dr. Chongyi Chen in the Laboratory of Biochemistry and Molecular Biology at the CCR, NCI, NIH in Bethesda, MD. The potential projects are to investigate the dynamics and regulation of DNA topology upon mitotic chromosome condensation, and to investigate the role of DNA topology in gene expression regulation in human cells. The Chen lab studies chromatin structure, DNA topology, and gene expression regulation in human cells, using various genomic technologies and single-cell sequencing assays newly invented in the lab.

The laboratory is located on the NIH main campus, together with >1000 labs, and >100 National Academy of Sciences/Medicine members. NIH postdocs have access to first-class research facilities, enjoy outstanding salary and benefits often better than their counterparts in universities. We are stably and sufficiently funded intramurally without the pressure of securing grants from time to time, thus have the privilege to focus on producing high-quality science.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Training Position (Stipend commensurate with experience)
Work Schedule
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

We are looking for candidates with strong backgrounds in molecular cell biology, genomics, bioinformatics, or related fields who are passionate and self-motivated in research. Candidates with prior experience in chromatin biology or omics data analysis are especially encouraged to apply.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
  • CV/Resume
Contact Information
Contact Name
Chongyi Chen
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.