Post-doctoral Fellow - Chemical immunology, protease biology

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Position is with
Name of Hiring Official/Investigator

Job Description

The Yoo laboratory, in the Chemical Biology Laboratory, CCR, NCI, has an opening for a postdoctoral fellow. The goal of our research project is to study functional proteases that play important roles as instigators and regulators of immune responses and understand how they shape the tumor microenvironment and dictate the fate of tumor cells. Our research focuses on the development and application of chemical strategies that allow kinetic and dynamic measurement of the network of protease activities. We use our expertise in synthetic chemistry to synthesize small molecules and peptidomimetics to probe and inhibit the activity of proteases and utilize biochemistry, structure biology, molecular biology, and chemical proteomics to characterize the protease-ligand interactions. To learn more about the research in the Yoo group, please visit

We are looking for enthusiastic and motivated chemical biologists to join our research team. We strive to create an open, diverse, and inclusive research environment and welcome researchers of all races, ethnicities, religions, gender identities, and sexual orientations. Women and candidates from underrepresented minorities are encouraged to apply.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Training Position (Stipend commensurate with experience)
Work Schedule
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills
  • A doctoral degree or expect to receive their degree shortly in chemical biology or related field
  • Proven problem-solving and communication skills
Preferred Skills
  • Experience in compound screening and hit validation with in vitro biochemical, biophysical assays and molecular biology are desired
  • Prior research experience and interest in immunology is preferable

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.

How to Apply
  • CV/Resume
  • Statement of Research Goals
  • Three References
  • Cover Letter
  • Summary of Research Experience
Contact Information
Contact Name
Euna Yoo
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.