Post-doctoral Fellow - Cell cycle, single-cell dynamics

Date Posted
Position is with
Name of Hiring Official/Investigator

Job Description

A postdoctoral position is available in the lab of Dr. Steven Cappell in the Laboratory of Cancer Biology and Genetics, CCR, NCI, NIH. Dr. Cappell is interested in understanding how signal transduction networks are wired to form logical circuits and how these networks function in space and time to regulate diverse aspects of human physiology. Our approach is to combine live-cell imaging of fluorescent biosensors in single cells with genetic and pharmacological perturbations to identify regulatory mechanisms of signal transduction pathways. In particular, we are interested in understanding how cells make the decision to enter the cell cycle and proliferate and how this decision is perturbed in cancer.

The postdoctoral fellow will investigate cell cycle dynamics in both normal and cancer cells using cutting-edge imaging and analysis tools. An additional goal of this project will be to combine live-cell imaging pipelines with single-cell RNA sequencing.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Training Position (Stipend commensurate with experience)
Work Schedule
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

A Ph.D. with less than 5 years post-graduate experience in cancer biology, cell biology, or related field is required. Alternatively, a Ph.D. in Computational Biology with a background/interest in cell biology and methods related to single-cell and image analysis will be considered. Cross-training between bench science and computational science will be available.

Preferred Skills

Ability to implement customized algorithms (MATLAB, R, python, etc.) is highly desirable.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
  • CV/Resume
  • 3 References
  • Cover Letter
Additional Application Information

Candidates should send a cover letter, current CV, and names of three references to: Steve Cappell, Successful candidates will be hired through the Cancer Research Training Award mechanism at the NIH (, which offers a competitive salary and generous benefits package. This position is subject to a background investigation.

Contact Information
Contact Name
Steven Cappell
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.