Post-doctoral Fellow - Cell biology, biochemistry, structural biology

Date Posted
Position is with
Name of Hiring Official/Investigator

Job Description

One postdoctoral position is immediately available with Dr. Kyung Lee in the Cancer Innovation Laboratory, CCR, NCI, to study Polo kinases and their associated scaffold proteins that orchestrate centrosomal organization, cell division, and tumorigenesis using cell biological, structural, and cryo-EM approaches.

Our research goal is to understand the function of mammalian polo-like kinase 4 and 1 (Plk4 and Plk1) that play central roles in regulating various biological events, including centriole duplication, bipolar spindle formation, chromosome segregation, cell division, and proliferation. During the past several years, we have been combining biochemical, cell biological, and structural approaches to delineate the molecular mechanisms governing Plk4/Plk1’s functionality on the centrosomal architecture, the deregulation of which can lead to the development of many human diseases, including cancer, microcephaly, and AIDS.

Qualifications and Job Details

Degree Required
Ph.D. or equivalent
Job Location
Appointment Type
Training Position (Stipend commensurate with experience)
Work Schedule
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills

We are looking for individuals who have an expertise in the field of cell biology (e.g., super-resolution imaging, in vitro reconstitution), X-ray crystallography, or cryo-EM and a keen interest in learning about the organization/function of the centrosome and their relevance to pathophysiological disorders, such as cancer and AIDS.

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.


Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
  • CV/Resume
Contact Information
Contact Name
Kyung Lee
E-mail Address
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.