A postdoctoral position is available in the Cancer Molecular Pathology section headed by Frederic G. Barr, M.D., Ph.D. in the Laboratory of Pathology, CCR, NCI, Bethesda, MD. This research laboratory uses a multidisciplinary approach involving genomics and bioinformatics along with cell culture and animal models to study genetic and epigenetic alterations in cancer. By initially focusing on specific cancer types, such as the rhabdomyosarcoma family of myogenic soft tissue cancers, this research laboratory is investigating the molecular basis, biological consequences and clinical significance of chromosomal translocations, amplification events, and methylation changes in these cancers. The methodologies, reagents and concepts from these studies are then being applied to address these issues in other relevant cancer categories. This is an exciting opportunity to join a growing and evolving cancer research effort across the basic, translational, and clinical research spectrum. Current projects in the laboratory are in the areas of:
1) Action of fusion oncoproteins (J. Pathol. - PMID: 28138962)
2) Mechanisms of tumor recurrence (Cancer Res. - PMID: 33589519),
3) Amplified genes as therapeutic targets (J. Clin. Invest. - PMID: 34166228),
4) DNA methylation-based classification (Int. J. Cancer - PMID: 30565669).
Qualifications and Job Details
Required and Preferred Skills
Interested candidates must have a doctoral degree with less than five years of relevant postdoctoral experience, and have a background in molecular biology, cell biology, biochemistry, genetics, or a related discipline.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.
This position is subject to a background investigation.