Dr. Mitchell Ho’s laboratory at the National Cancer Institute's (NCI's) Center for Cancer Research (CCR) has characterized cell surface proteins such as glypicans including GPC1, GPC2 and GPC3, B7-H3 (CD276), and mesothelin as immunotherapeutic targets in solid tumors such as liver cancer, pancreatic cancer and childhood cancers. We have used molecular and cellular biology, computational structure modeling, RNA sequencing (RNA-seq), and mouse tumor models to develop single-domain antibody (nanobody) technology, isolate antibodies targeting tumor-specific epitopes, and engineer CAR or TCR constructs for designing novel T cell-based immunotherapies. There are two postdoctoral positions available in the Ho lab, one for antibody discovery (phage display) and protein engineering in the antibody engineering core and the other for T cell engineering and preclinical testing using mouse tumor models in the antibody therapy section. Some of our research studies have the potential for direct clinical application.
Detailed information about our research program and publications can be accessed at: https://ccr.cancer.gov/mitchell-ho
Qualifications and Job Details
Required and Preferred Skills
Candidates are expected to have completed, or be completing, a Ph.D. or M.D./Ph.D. with a strong publication record. Highly motivated candidates who are interested in innovative, high-impact basic and translational research are encouraged to apply. A background in biochemistry, molecular and cell biology, and/or biomedical engineering is required.
Experience with mouse tumor models, RNA-seq, protein structure and/or computational skills is a plus.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.