Two postbaccalaureate positions are available (2023-2025) to study the role of Wnt signaling pathways in stem cell self-renewal and differentiation. We are studying a population of multipotent axial progenitors, called neuromesodermal progenitors (NMPs), which arise during gastrulation and generate the spinal cord and somites of the trunk and tail. The Wnt/beta-catenin signaling pathway activates gene regulatory networks (GRNs) to regulate NMP development. The candidate will study how transcription factors function in these GRNs to regulate NMP self-renewal and differentiation. Our studies are largely focused on the mouse embryo but Xenopus (Frog) and embryonic stem cell-based in vitro differentiation models, including gastruloid/organoid 3D cultures, are also employed. Candidates will gain experience with a variety of genomic, cellular, molecular and developmental biology techniques.
Qualifications and Job Details
Required and Preferred Skills
A keen interest in developmental or molecular biology is required.
Experience with molecular biology is preferred but not required.
About the NCI Center for Cancer Research
The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.
Frederick is the second largest city in Maryland but retains a “small town” feel, surrounded by mountain views with a vibrant Main Street community. The city offers outstanding schools, a balanced and thriving economy and a highly educated workforce.
The Yamaguchi lab embraces diversity, equality and inclusion. We are committed to building a team with a variety of backgrounds, skills and views and to providing a non-discriminatory environment that fosters learning, creativity and innovation.