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Clinical Research Physician - Hairy Cell Leukemia, recombinant immunotoxin

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Job Description

We are currently seeking a clinician who is board certified or board eligible in medical oncology and/or hematology to join the Clinical Immunotherapy Section of the Laboratory of Molecular Biology, where we focus on targeted therapy for hematologic malignancies, particularly hairy cell leukemia (HCL), and other new therapies for HCL. Moxetumomab pasudotox (Moxe) contains truncated Pseudomonas exotoxin (PE) fused to an anti-CD22 Fv fragment. Previously called HA22 or CAT-8015, it is an affinity-matured form of a previous molecule BL22 for targeting hematologic malignancies, particularly HCL. We have recently opened a CAT-T protocol targeting CD22.  We test combinations of chemotherapy and rituximab to help determine the optimal therapy of newly diagnosed and multiply relapsed HCL, and to better understand the behavior of HCL in immunotoxin-treated patients.  We also test small molecules targeted to BRAF-MEK or BTK.  In the lab, which interacts with the clinical research team, we use clinical samples from patients to investigate treatment efficacy and toxicity, and to better understand the biology and pathogenesis of leukemias through whole exome and RNA transcriptome sequencing.

Qualifications and Job Details

Degree Required
M.D. or equivalent
Job Location
Bethesda
Appointment Type
Government Position (Salary commensurate with experience)
Work Schedule
Full-time
Citizenship
US Citizenship not required - (ie, permanent resident, visa)

Required and Preferred Skills

Required Skills
  • Hematologic Oncology patient care
  • Writing up clinical data for publications and meeting presentations
  • Protocol development, serving as associate or principal investigator on trials
  • Interact with clinical team of research nurses, NP, patient care coordinators, and data managers

About the NCI Center for Cancer Research

The Center for Cancer Research (CCR) is home to nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. CCR is part of the National Cancer Institute (NCI) and makes up the largest component of the research effort at the National Institutes of Health (NIH). Centrally supported by long-term funding and a culture of complete intellectual freedom, CCR scientists are able to pursue the most important and challenging problems in cancer research. We collaborate with academic and commercial partners and advocacy groups across the world in efforts to prevent, diagnose and treat cancer and HIV/AIDS. The CCR research portfolio covers the full spectrum of biological and biomedical research. Our work ranges from basic to translational and clinical, and our clinical trials are conducted in the NIH Clinical Center, the world’s largest hospital dedicated to clinical research that offers a robust infrastructure to support CCR’s patients on an estimated 250 open studies. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights from bench to bedside. Read more about CCR, the benefits of working at CCR and hear from our staff on their CCR experiences.

Bethesda

Bethesda is one of the most highly educated communities in the United States and has a nationally renowned school system. The city is a thriving suburban center close to Washington, D.C., and home to many restaurants, retailers and a flourishing arts and entertainment district.

How to Apply
Submit:
  • CV/Resume
  • 2 References
  • Cover Letter
Contact Information
Contact Name
Robert Kreitman
E-mail Address
kreitmar@mail.nih.gov
DHHS, NIH and NCI are equal opportunity employers. The NCI and CCR are deeply committed to diversity of thought, equity and inclusion and encourage applications from qualified women, underrepresented minorities and individuals with disabilities.