Pediatric Oncology Branch: Hematogic Diseases

Hematologic diseases team, 2011

The primary goal of the hematologic diseases program is to develop new treatment strategies for hematologic malignancies, the most frequent cancer type in pediatrics. Although cure rates are excellent for many subtypes of childhood leukemia and lymphoma, new approaches are needed to overcome resistance to standard therapies and to decrease treatment-associated sequelae in survivors of pediatric cancer. We conduct collaborative pre-clinical, translational, and clinical studies that focus on developing targeted agents and applying immunotherapy to direct anti-tumor responses for childhood leukemias and lymphomas.

Dr. Fry with patient

Current activities include:

  •  Development of anti-CD19, anti-CD22 and anti-CD33 chimeric antigen receptor (CAR) therapy and other targeted agents and immune-based therapies
  • Novel approaches to hematopoietic stem cell transplantation, with a focus on immune restoration and treatment of patients with primary immune deficienies
  • Post-transplant allogeneic immunotherapy to direct anti-tumor responses and treatment of relapse after transplant
  • Pre-clinical studies designed to support current and future translational trials, to apply new methods in the study of cellular, molecular, genetic, and genomic biology, and to probe for new therapeutic targets    
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little girl at playground

Collaborative studies include:

  • Neurotoxicity of CAR and other novel immunotherapies
  • Education of minors who donate stem cells

Nurse Practitioners

  • Bonnie Yates, CRNP

Research Nurses

  • Cindy Delbrook, RN

Data Managers

  • Ekaterina Nikitina
  • Showri Kakumanu

Clinic Coordinator

  • Terri Moore