Laboratory of Genitourinary Cancer Pathogenesis

Chief
Kathleen Kelly Siebenlist, Ph.D.

LGCP Branch PhotoThe Laboratory of Genitourinary Cancer Pathogenesis (LGCP) focuses on genitourinary (GU) cancers, especially prostate cancer, with the goal of understanding fundamental processes of cancer pathogenesis and translating this knowledge into clinical applications. We work within the Urologic Oncology Collaborative Group, which brings together integrated basic and translational research, surgical oncology, and medical oncology for the purpose of improving the detection, diagnosis, and treatment of patients with GU cancers. Specifically, LGCP includes mechanism-oriented research programs to investigate 1) the action of common prostate cancer genomic mutations, 2) microenvironmental influences on tumor progression and metastasis development, 3) castration resistance and prostate cancer stem cells, and 4) the regulation of responses to cell death pathways.

Position Contact Name Contact E-mail Contact Phone Research Area Keywords Number of Positions
Postdoctoral Fellow Adam Sowalsky

adam.sowalsky@nih.gov

301-435-4652

genomics, drug resistance, biomarkers, bioinformatics

1
Postdoctoral Fellow David VanderWeele

david.vanderweele@nih.gov

301-443-2622

molecular biology, genetics, drug resistance, biomarkers

1

The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) Microscopy Core provides training, guidance, and state-of-the-art service to LCGP scientists as well as other NCI-CCR researchers who require in vivo imaging or confocal microscopy techniques as part of their research efforts.

The LGCP Microscopy Core currently houses:

  • A Carl Zeiss LSM 780 laser scanning confocal microscope equipped with two PMTs and one 32 channel GaAsP spectral detector.
  • An Olympus VivaView fluorescence incubator microscope for long-term live cell imaging
  • Two Zeiss AxioObserver.Z1 epifluorescent scopes equipped with a digital camera and Zen software.
  • A Zeiss AxioScan.Z1 slide scanner capable of imaging fluorescent or brightfield slides

Please visit the Microscopy Core Facility website for more information about our equipment, sample images, publications, and instrument scheduling. Image acquisition and analysis is provided free of charge.

Scientists who are fully trained in confocal microscopy work independently while inexperienced users are encouraged to arrange for training or to establish a collaboration with Ross Lake.

Post-Bacc, Lauren Stahl featured on AACR's website https://www.aacrfoundation.org/Stories/Pages/lauren-elizabeth-stahl.aspx

May 26-LGCP Guest Speaker, Joshua Lang. Building 37 room 4041/4107 2pm-3pm. "Translational Biomarkers in Prostate Cancer: Intersection of Engineering, Biology and Clinical Care"

April 7 2016-GU Center of Excellence sponsored talk by Dr. Steve Balk Building 50 lobby room 1227/1233 12pm-1pm  "Mechanisms Driving Resistance to New Androgen Receptor Targeted Therapies in Prostate Cancer."

 

 

About

LGCP Branch PhotoThe Laboratory of Genitourinary Cancer Pathogenesis (LGCP) focuses on genitourinary (GU) cancers, especially prostate cancer, with the goal of understanding fundamental processes of cancer pathogenesis and translating this knowledge into clinical applications. We work within the Urologic Oncology Collaborative Group, which brings together integrated basic and translational research, surgical oncology, and medical oncology for the purpose of improving the detection, diagnosis, and treatment of patients with GU cancers. Specifically, LGCP includes mechanism-oriented research programs to investigate 1) the action of common prostate cancer genomic mutations, 2) microenvironmental influences on tumor progression and metastasis development, 3) castration resistance and prostate cancer stem cells, and 4) the regulation of responses to cell death pathways.

PI & Key Staff

Positions

Position Contact Name Contact E-mail Contact Phone Research Area Keywords Number of Positions
Postdoctoral Fellow Adam Sowalsky

adam.sowalsky@nih.gov

301-435-4652

genomics, drug resistance, biomarkers, bioinformatics

1
Postdoctoral Fellow David VanderWeele

david.vanderweele@nih.gov

301-443-2622

molecular biology, genetics, drug resistance, biomarkers

1

Cores

The Laboratory of Genitourinary Cancer Pathogenesis (LGCP) Microscopy Core provides training, guidance, and state-of-the-art service to LCGP scientists as well as other NCI-CCR researchers who require in vivo imaging or confocal microscopy techniques as part of their research efforts.

The LGCP Microscopy Core currently houses:

  • A Carl Zeiss LSM 780 laser scanning confocal microscope equipped with two PMTs and one 32 channel GaAsP spectral detector.
  • An Olympus VivaView fluorescence incubator microscope for long-term live cell imaging
  • Two Zeiss AxioObserver.Z1 epifluorescent scopes equipped with a digital camera and Zen software.
  • A Zeiss AxioScan.Z1 slide scanner capable of imaging fluorescent or brightfield slides

Please visit the Microscopy Core Facility website for more information about our equipment, sample images, publications, and instrument scheduling. Image acquisition and analysis is provided free of charge.

Scientists who are fully trained in confocal microscopy work independently while inexperienced users are encouraged to arrange for training or to establish a collaboration with Ross Lake.

Contact Info

Laboratory of Genitourinary Cancer Pathogenesis
Center for Cancer Research
National Cancer Institute
Building 37, Room 1068
Bethesda, MD 20892-4263
Ph: 301-435-4651
Administrative Lab Manager
301-435-4652
Technical Lab Manager
301-402-4869