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If you are interested in interviewing a CCR scientist, OR you are a scientist who has been contacted by a member of the media, please contact the NCI Press Office at ncipressofficers@mail.nih.gov or by phone at 240.760.6600.

Our Discoveries

New CAR T-cell therapy eliminates rhabdomyosarcoma in mice

After seeing excellent results of a CAR T-cell therapy against rhabdomyosarcoma in mice, a team of CCR researchers is preparing to test the immunotherapy in humans.

New findings highlight shared features of human and canine osteosarcoma

Molecular signatures of canine osteosarcoma prognosis could also predict clinical outcomes for human osteosarcomas.

Shining a light on an elusive cancer metabolite

Researchers have long sought a means for subcellular imaging of acetyl-CoA, a metabolite suspected to play a critical role in turning genes on and off. In an important advance, CCR researchers have invented a glowing biosensor to detect the elusive metabolite, paving the way for future studies.

Seldom-studied immune cells in the liver may be helpful in treating cancer

CCR researchers have discovered that certain immune cells in the liver, called MAITs, often surround liver tumors but fail to infiltrate them. An analysis suggests that treatment with immune checkpoint inhibitors could potentially trigger these immune cells to help them infiltrate and attack the tumors.

A stain of HPV-negative head and neck squamous cell carcinoma that has high levels of SMYD3

Chromatin modifier linked to immunotherapy resistance in HPV-negative head and neck cancers

Researchers have discovered that a chromatin-regulating enzyme called SMYD3 limits the access of cancer-attacking immune cells to HPV-negative head and neck cancers, therefore decreasing immunotherapy’s effectiveness. Depleting SMYD3 increased the cancer’s sensitivity to a standard immunotherapy drug in mouse models.

New insights explain how the same protein can serve different functions

Proteins can often choose between potential interacting partners and serve different functions inside cells. How these choices are made is not entirely clear. New research shows that the exact location in a cell where the protein is produced and the rate of its synthesis are key factors in this choice.