Clinical Trials
Clinical trial studies antitumor effect of sunitinib in central nervous system sarcomas
A new clinical trial is testing a cancer drug, sunitinib, on recurrent gliosarcoma and previously treated sarcomas of the central nervous system. This drug has been studied in several other types of cancer, where it was able to inhibit factors that help tumors grow and spread. Investigators want to see if sunitinib can have the same antitumor effect on sarcomas and gliosarcoma of the brain and spinal cord.
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Clinical trial finds combination therapy effective for some biliary cancer patients
Completion of a phase I/II clinical trial found that two of 20 patients with biliary tract cancer disease experienced a partial response to treatment with the immune checkpoint inhibitor tremelimumab combined with microwave ablation therapy. Further studies are needed to understand why just a few patients responded well to this combination treatment.
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New imaging technology to detect early-stage hereditary diffuse gastric cancer tested in clinical trial
Hereditary diffuse gastric cancer is a rare inherited condition caused by a mutation in the CDH1 gene. People who carry this genetic mutation are urged to have a screening endoscopy followed by surgery to remove the stomach. However, some patients elect to have regular endoscopic screenings to look for cancer. A new clinical trial is testing an imaging technology called confocal endoscopic microscopy (CEM) that may better detect cells in patients with the CDH1 mutation and potentially make a diagnosis during the endoscopy itself.
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New clinical program will study metastatic colorectal cancer in viable patient tissue samples
Jonathan Hernandez, M.D., Investigator in the Thoracic and Gastrointestinal Oncology Branch, has established a new clinical program to understand how metastases form, which may yield insights into how to treat or even prevent them. The program will conduct first-of-their-kind studies with tumor-containing liver that is kept alive outside of the body after it is removed from a patient. Read more…
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