Yinling Hu, Ph.D.
Yinling  Hu, Ph.D.
Investigator
Head, Inflammation and Tumorigenesis Section

Dr. Hu's research focuses on understanding the physiological activities of IKKα in skin tumorigenesis and inflammation and in revealing the mechanisms by which IKKα regulates these functions by using genetic animal models, including Ikkα conditional knockout, Ikkα kinase inactive knockin and IKKα transgenic mice, as well as molecular biology approaches.

Areas of Expertise
1) IKKα, 2) tumorigenesis 3) inflammation

Contact Info

Yinling Hu, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 567, Room 252
Frederick, MD 21702-1201
301-846-1478
huy2@mail.nih.gov

The research interests of the Inflammation and Tumorigenesis Section are to understand the physiological activities of IKKα in skin tumorigenesis and inflammation and to reveal the mechanisms by which IKKα regulates these functions using genetic animal models, including Ikkα conditional knockout, Ikkα kinase inactive knockin and IKKα transgenic mice, as well as molecular biology approaches.

Scientific Focus Areas:
Cancer Biology, Chromosome Biology, Immunology, Molecular Biology and Biochemistry
Selected Recent Publications
  1. Göktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR
    Cell Rep. 7: 1914-25, 2014. [ Journal Article ]
  2. Xia X, Liu S, Xiao Z, Zhu F, Song NY, Zhou M, Liu B, Shen J, Nagashima K, Veenstra TD, Burkett S, Datla M, Willette-Brown J, Shen H, Hu Y
    Cell Rep. 5: 1243-55, 2013. [ Journal Article ]
  3. Jellusova J, Miletic AV, Cato MH, Lin WW, Hu Y, Bishop GA, Shlomchik MJ, Rickert RC
    Cell Rep. 5: 1022-35, 2013. [ Journal Article ]
  4. Xia X, Park E, Fischer SM, Hu Y
    Cancers (Basel). 5: 170-83, 2013. [ Journal Article ]
  5. Xiao Z, Jiang Q, Willette-Brown J, Hu Y
    Oncotarget. 4: 810-1, 2013. [ Journal Article ]

Dr. Hu received her undergraduate degree from the Chinese Academy of Medical Science (Beijing, China) and received her Ph.D from the University of Melbourne, (Melbourne, Australia). She was a postdoctoral fellow in Michael Karin's laboratory, University of California at San Diego from 1996 to 2001. Dr. Hu established her own laboratory in 2001 when she became an assistant professor at the Science Park Research Division, MD Anderson Cancer Center.  In 2008 she became a principal investigator in the Laboratory of Experimental Immunology, Cancer and Inflammation Program at NCI at Frederick.

Name Position
Zane Gray Summer Student
Weidong Li Guest Researcher
Na-Young Song Postdoctoral Fellow (Visiting)
Xin Wei Wang, Ph.D. Special Volunteer
Jami Willette-Brown M.S. Research Biologist
Zuoxiang Xiao Research Fellow
Feng Zhu Research Fellow

Research

The research interests of the Inflammation and Tumorigenesis Section are to understand the physiological activities of IKKα in skin tumorigenesis and inflammation and to reveal the mechanisms by which IKKα regulates these functions using genetic animal models, including Ikkα conditional knockout, Ikkα kinase inactive knockin and IKKα transgenic mice, as well as molecular biology approaches.

Scientific Focus Areas:
Cancer Biology, Chromosome Biology, Immunology, Molecular Biology and Biochemistry

Publications

Selected Recent Publications
  1. Göktuna SI, Canli O, Bollrath J, Fingerle AA, Horst D, Diamanti MA, Pallangyo C, Bennecke M, Nebelsiek T, Mankan AK, Lang R, Artis D, Hu Y, Patzelt T, Ruland J, Kirchner T, Taketo MM, Chariot A, Arkan MC, Greten FR
    Cell Rep. 7: 1914-25, 2014. [ Journal Article ]
  2. Xia X, Liu S, Xiao Z, Zhu F, Song NY, Zhou M, Liu B, Shen J, Nagashima K, Veenstra TD, Burkett S, Datla M, Willette-Brown J, Shen H, Hu Y
    Cell Rep. 5: 1243-55, 2013. [ Journal Article ]
  3. Jellusova J, Miletic AV, Cato MH, Lin WW, Hu Y, Bishop GA, Shlomchik MJ, Rickert RC
    Cell Rep. 5: 1022-35, 2013. [ Journal Article ]
  4. Xia X, Park E, Fischer SM, Hu Y
    Cancers (Basel). 5: 170-83, 2013. [ Journal Article ]
  5. Xiao Z, Jiang Q, Willette-Brown J, Hu Y
    Oncotarget. 4: 810-1, 2013. [ Journal Article ]

Biography

Dr. Hu received her undergraduate degree from the Chinese Academy of Medical Science (Beijing, China) and received her Ph.D from the University of Melbourne, (Melbourne, Australia). She was a postdoctoral fellow in Michael Karin's laboratory, University of California at San Diego from 1996 to 2001. Dr. Hu established her own laboratory in 2001 when she became an assistant professor at the Science Park Research Division, MD Anderson Cancer Center.  In 2008 she became a principal investigator in the Laboratory of Experimental Immunology, Cancer and Inflammation Program at NCI at Frederick.

Team

Name Position
Zane Gray Summer Student
Weidong Li Guest Researcher
Na-Young Song Postdoctoral Fellow (Visiting)
Xin Wei Wang, Ph.D. Special Volunteer
Jami Willette-Brown M.S. Research Biologist
Zuoxiang Xiao Research Fellow
Feng Zhu Research Fellow