William C. Reinhold, B.S.
William C. Reinhold, B.S.
Facility Head
Head, Genomics and Bioinformatics Group

Center for Cancer Research
National Cancer Institute

Building 37, Room 5401
Bethesda, MD 20892-4255
301-496-9571

William Reinhold runs the CellMiner website , generates data for inclusion in it, organizes that data in an intuitive fashion, develops the software to facilitate the use of that data, and accesses that data scientifically. CellMiner includes data for the NCI-60 cancerous cell lines, and is a premier systems pharmacology resource, including data from 18 platforms. We provide the unmatched Developmental Therapeutics Program  activity data for 20,002 compounds (including 114 FDA-approved drugs, and 55 in clinical trial). Multiple forms of molecular data is provided. The user may select any of these input parameters of interest (e.g., a gene, drug, microRNA) for cross comparison.

Areas of Expertise
pharmacology, website, cancer, pharmacogenomics, molecular data

Currently our research includes the collection of data for the NCI-60 cancerous cell lines, and the development of software to facilitate the use of this data in systems pharmacology. We currently provide easy integration for 20, 602 compounds (including 102 FDA-approved drugs, and 53 in clinical trial), 26,065 genes, and 350 microRNAs. The user selects their input parameter of interest (example: a gene, drug, microRNA, or any other criteria of interest).

Selected Publications
  1. Reinhold WC, Sunshine M, Liu H, Varma S, Kohn KW, Morris J, Doroshow J, Pommier Y.
    Cancer Res.. 72: 3499-511, 2012. [ Journal Article ]
  2. Reinhold WC, Reimers MA, Lorenzi P, Ho J, Shankavaram UT, Ziegler MS, Bussey KJ, Nishizuka S, Ikediobi O, Pommier YG, Weinstein JN.
    Mol. Cancer Ther.. 9: 41655, 2010. [ Journal Article ]
  3. Reinhold WC, Mergny JL, Liu H, Ryan M, Pfister TD, Kinders R, Parchment R, Doroshow J, Weinstein JN, Pommier Y.
    Cancer Res.. 70: 2191-203, 2010. [ Journal Article ]
  4. Zoppoli G, Regairaz M, Leo E, Reinhold WC, Varma S, Ballestrero A, Doroshow JH, Pommier Y.
    Proc. Natl. Acad. Sci. U.S.A.. 109: 15030-5, 2012. [ Journal Article ]
  5. Abaan OD, Polley EC, Davis SR, Zhu YJ, Bilke S, Walker RL, Pineda M, Gindin Y, Jiang Y, Reinhold WC, Holbeck SL, Simon RM, Doroshow JH, Pommier Y, Meltzer PS.
    Cancer Res.. 73: 4372-82, 2013. [ Journal Article ]

William Reinhold is currently operating as facility head of the Genomics and Bioinformatics Group in the Laboratory of Molecular Pharmacology. He has been a part of this section since April 1998, working with first John N. Weinstein, and then Yves Pommier. He has been central in generating multiple datasets for the NCI-60 cancerous cell lines, available at the CellMiner web-application at http://discover.nci.nih.gov/cellminer/. His activities include running the web site, and maintaining the contracts required to do so, as a Contracting Officer Representative (COR). He helps in the dissemination and interpretation of this data, encouraging and facilitation collaborations. Prior to this period of time he has also held positions with the Laboratory of Molecular Pharmacology (Sept. 1996 to April 1998), Laboratory of Biological Chemistry and Medicine Branch in the NCI (February 1992 - September 1996), at the National Institutes of Neurological Diseases and Stroke (Sept.-1989 to Feb.-1992), National Institutes of Allergies and Infectious Diseases June 1982 to Aug. 1989), as well as in private industry, working for Gibco BRL (April 1981 to Feb. 1982), and Meloy Laboratories (Jan. 1978 to April 1981). He received his B.S. in Biochemistry from the University of Maryland in 1978, and has 66 pier reviewed publications to date.

Name Position
Vinodh Rajapakse Ph.D. Postdoctoral Fellow (CRTA)
Margot Sunshine Ph.D. Computer Specialist (Contr)
Sudhir Varma Ph.D. Bioinformatics Specialist (Contr)
Barry R. Zeeberg Ph.D. Staff Scientist

Summary

William Reinhold runs the CellMiner website , generates data for inclusion in it, organizes that data in an intuitive fashion, develops the software to facilitate the use of that data, and accesses that data scientifically. CellMiner includes data for the NCI-60 cancerous cell lines, and is a premier systems pharmacology resource, including data from 18 platforms. We provide the unmatched Developmental Therapeutics Program  activity data for 20,002 compounds (including 114 FDA-approved drugs, and 55 in clinical trial). Multiple forms of molecular data is provided. The user may select any of these input parameters of interest (e.g., a gene, drug, microRNA) for cross comparison.

Areas of Expertise
pharmacology, website, cancer, pharmacogenomics, molecular data

Research

Currently our research includes the collection of data for the NCI-60 cancerous cell lines, and the development of software to facilitate the use of this data in systems pharmacology. We currently provide easy integration for 20, 602 compounds (including 102 FDA-approved drugs, and 53 in clinical trial), 26,065 genes, and 350 microRNAs. The user selects their input parameter of interest (example: a gene, drug, microRNA, or any other criteria of interest).

Publications

Selected Publications
  1. Reinhold WC, Sunshine M, Liu H, Varma S, Kohn KW, Morris J, Doroshow J, Pommier Y.
    Cancer Res.. 72: 3499-511, 2012. [ Journal Article ]
  2. Reinhold WC, Reimers MA, Lorenzi P, Ho J, Shankavaram UT, Ziegler MS, Bussey KJ, Nishizuka S, Ikediobi O, Pommier YG, Weinstein JN.
    Mol. Cancer Ther.. 9: 41655, 2010. [ Journal Article ]
  3. Reinhold WC, Mergny JL, Liu H, Ryan M, Pfister TD, Kinders R, Parchment R, Doroshow J, Weinstein JN, Pommier Y.
    Cancer Res.. 70: 2191-203, 2010. [ Journal Article ]
  4. Zoppoli G, Regairaz M, Leo E, Reinhold WC, Varma S, Ballestrero A, Doroshow JH, Pommier Y.
    Proc. Natl. Acad. Sci. U.S.A.. 109: 15030-5, 2012. [ Journal Article ]
  5. Abaan OD, Polley EC, Davis SR, Zhu YJ, Bilke S, Walker RL, Pineda M, Gindin Y, Jiang Y, Reinhold WC, Holbeck SL, Simon RM, Doroshow JH, Pommier Y, Meltzer PS.
    Cancer Res.. 73: 4372-82, 2013. [ Journal Article ]

Biography

William Reinhold is currently operating as facility head of the Genomics and Bioinformatics Group in the Laboratory of Molecular Pharmacology. He has been a part of this section since April 1998, working with first John N. Weinstein, and then Yves Pommier. He has been central in generating multiple datasets for the NCI-60 cancerous cell lines, available at the CellMiner web-application at http://discover.nci.nih.gov/cellminer/. His activities include running the web site, and maintaining the contracts required to do so, as a Contracting Officer Representative (COR). He helps in the dissemination and interpretation of this data, encouraging and facilitation collaborations. Prior to this period of time he has also held positions with the Laboratory of Molecular Pharmacology (Sept. 1996 to April 1998), Laboratory of Biological Chemistry and Medicine Branch in the NCI (February 1992 - September 1996), at the National Institutes of Neurological Diseases and Stroke (Sept.-1989 to Feb.-1992), National Institutes of Allergies and Infectious Diseases June 1982 to Aug. 1989), as well as in private industry, working for Gibco BRL (April 1981 to Feb. 1982), and Meloy Laboratories (Jan. 1978 to April 1981). He received his B.S. in Biochemistry from the University of Maryland in 1978, and has 66 pier reviewed publications to date.

Team

Name Position
Vinodh Rajapakse Ph.D. Postdoctoral Fellow (CRTA)
Margot Sunshine Ph.D. Computer Specialist (Contr)
Sudhir Varma Ph.D. Bioinformatics Specialist (Contr)
Barry R. Zeeberg Ph.D. Staff Scientist