Wenqing Li, Ph.D.
Wenqing  Li, Ph.D.
Staff Scientist

Dr. Li studies the intracellular pathways related to IL-7's effects on T cell apoptosis and proliferation. She found that IL-7 promotes T cell survival and division by blocking degradation of Mcl-1 and inducing degradation of the cell cycle inhibitor p27kip1. Her current work focuses on identifying the ubiquitination pathways that IL-7 uses to control the stability of Mcl-1 and p27kip1 in T cells. The same pathways used by IL-7 may be preempted in carcinogenesis, since Mcl-1 is an oncogene and p27kip1 is a tumor suppressor.

Areas of Expertise
1) IL-7, 2) T cell apoptosis and proliferation

Contact Info

Wenqing Li, Ph.D.
Center for Cancer Research
National Cancer Institute
Bldg. 560 /Rm. 31-46
Frederick, MD 21702-1201
301-846-6977
liwenq@mail.nih.gov

Dr. Li's research goal is to understand the intracellular pathways related to the IL-7's effects on T cell apoptosis and proliferation. She found that IL-7 promotes T cell survival and division by blocking degradation of Mcl-1 and inducing degradation of the cell cycle inhibitor p27kip1. Her current work is focused on identifying the ubiquitination pathways that IL-7 uses to control the stability of Mcl-1 and p27kip1 in T cells. The same pathways used by IL-7 may be preempted in carcinogenesis, since Mcl-1 is an oncogene and p27kip1 is a tumor suppressor.

Selected Publications
  1. Shen W, Li W, Hixon JA, Bouladoux N, Belkaid Y, Dzutzev A, Durum SK.
    Proc. Natl. Acad. Sci. U.S.A. 111: E2977-86, 2014. [ Journal Article ]
  2. Hanson ML, Hixon JA, Li W, Felber BK, Anver MR, Stewart CA, Janelsins BM, Datta SK, Shen W, McLean MH, Durum SK.
    Gastroenterology. 146 : 210-221, 2014. [ Journal Article ]
  3. Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y.
    Cell Death Differ. 19: 1139-51, 2012. [ Journal Article ]
  4. Ruppert SM, Li W, Zhang G, Carlson AL, Limaye A, Durum SK, Khaled AR.
    Biochim. Biophys. Acta. 1823: 1877-93, 2012. [ Journal Article ]
  5. Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT.
    Nat. Genet. 43: 932-9, 2011. [ Journal Article ]

Dr. Li received her B.S. and M.S. in biochemistry from Zhongshan (Sun Yat-sen) University, China, and obtained her Ph.D. in biomedical sciences from the University of Montreal. In 2001, she joined the Laboratory of Molecular Immunoregulation under Dr. Scott Durum working on the molecular mechanisms of IL-7 in T cell development and homeostasis. She was a postdoctoral and research fellow before becoming the staff scientist in this laboratory.

Research

Dr. Li's research goal is to understand the intracellular pathways related to the IL-7's effects on T cell apoptosis and proliferation. She found that IL-7 promotes T cell survival and division by blocking degradation of Mcl-1 and inducing degradation of the cell cycle inhibitor p27kip1. Her current work is focused on identifying the ubiquitination pathways that IL-7 uses to control the stability of Mcl-1 and p27kip1 in T cells. The same pathways used by IL-7 may be preempted in carcinogenesis, since Mcl-1 is an oncogene and p27kip1 is a tumor suppressor.

Publications

Selected Publications
  1. Shen W, Li W, Hixon JA, Bouladoux N, Belkaid Y, Dzutzev A, Durum SK.
    Proc. Natl. Acad. Sci. U.S.A. 111: E2977-86, 2014. [ Journal Article ]
  2. Hanson ML, Hixon JA, Li W, Felber BK, Anver MR, Stewart CA, Janelsins BM, Datta SK, Shen W, McLean MH, Durum SK.
    Gastroenterology. 146 : 210-221, 2014. [ Journal Article ]
  3. Kibe R, Zhang S, Guo D, Marrero L, Tsien F, Rodriguez P, Khan S, Zieske A, Huang J, Li W, Durum SK, Iwakuma T, Cui Y.
    Cell Death Differ. 19: 1139-51, 2012. [ Journal Article ]
  4. Ruppert SM, Li W, Zhang G, Carlson AL, Limaye A, Durum SK, Khaled AR.
    Biochim. Biophys. Acta. 1823: 1877-93, 2012. [ Journal Article ]
  5. Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT.
    Nat. Genet. 43: 932-9, 2011. [ Journal Article ]

Biography

Dr. Li received her B.S. and M.S. in biochemistry from Zhongshan (Sun Yat-sen) University, China, and obtained her Ph.D. in biomedical sciences from the University of Montreal. In 2001, she joined the Laboratory of Molecular Immunoregulation under Dr. Scott Durum working on the molecular mechanisms of IL-7 in T cell development and homeostasis. She was a postdoctoral and research fellow before becoming the staff scientist in this laboratory.