Cancer, Genetics, and Signaling Fellows Programs

The Cancer, Genetics, and Signaling (CGS) Group at the National Cancer Institute at Frederick  offers a competitive postdoctoral training and mentoring program focusing on molecular and genetic aspects of cancer. The CGS Fellows Program is designed to attract and train exceptional postdoctoral fellows interested in pursuing independent research career tracks. CGS Fellows participate in a structured mentoring program designed for scientific and career development and transition to independent positions. The CGS Fellows Program features weekly laboratory meetings, a Distinguished Scientist seminar series and a rich research environment. Supplemental funds for travel to scientific meetings will be provided. Investigators in the program have a strong history of placing postdoctoral trainees in tenure-track assistant professor (or equivalent) positions of leadership. 


Funding Resources

CGS Fellows are supported by the mentor’s resources. However, a limited number of bridge positions are available to supplement the first year of training if the mentor does not have an immediate opening. Trainees are also encouraged to apply for outside funding such as postdoctoral training and transition grants (e.g., K99, K22) to enhance their career development. Supplemental funds for travel to scientific meetings may be available.


The Campus

The NCI Center for Cancer Research (CCR) campus in Frederick, Maryland offers state-of-the-art mouse genetics, proteomics, and high-throughput sequencing core facilities, as well as drug discovery, structural biology, and other advanced technologies


To Apply

Applicants should be within one (1) year of receiving their Ph.D./M.D. degree and not more than two (2) years past their degree. To apply to the CGS Fellows Program, candidates should contact one or more of the participating investigators to determine if there is mutual interest. The investigator will subsequently forward the candidate’s application to the CGSFP Steering Committee for evaluation. Further questions should be directed to Dr. Peter Johnson or Dr. Susan Mackem, co-Chairs of the CGSFP Steering Committee, or Cheri Rhoderick.

The National Cancer Institute, National Institutes of Health is an equal opportunity/ affirmative action employer. Qualified women, minorities, and individuals with disabilities are encouraged to apply.


Interactive and Multidisciplinary

The CGS group is highly interactive and multidisciplinary and includes 19 principal investigators from 4 departments: Cancer and Developmental Biology, Cell and Developmental Signaling, Protein Dynamics and Signaling, and Mouse Cancer Genetics. Fields of research include the identification and characterization of novel oncogenes and tumor suppressors, control of cell proliferation and survival, epigenetics, transcriptional and translational regulation, signal transduction, RNA biology, mouse models of cancer and development, normal and cancer stem cells, and translational studies in preclinical models. For more detailed descriptions of the research interests of participating faculty members, please follow the links below. 


Participating Investigators and Research Interests

Cancer and Developmental Biology Laboratory

  • Jairaj Acharya - In vivo study of sphingolipid/phospholipid signaling
  • Ira Daar - Cell adhesion and movement in morphogenesis
  • Mark Lewandoski - Genetics of vertebrate development with an emphasis on FGF and BMP signaling
  • Susan Mackem - Regulatory networks in vertebrate patterning and morphogenesis
  • Alan Perantoni - Signaling mechanisms in renal progenitor specification and patterning
  • Terry Yamaguchi - Wnt signaling pathways and stem cells in the vertebrate embryo

Laboratory of Cell and Developmental Signaling

  • John Brognard - Novel tumor suppressing and oncogenic kinases
  • Deborah Morrison - Molecular mechanisms of Ras pathway regulation in normal and oncogenic signaling
  • Esta Sterneck - Molecular mechanisms of mammary and breast tumor cell development and metastatic progression
  • Christopher Westlake - Membrane trafficking pathways in primary cilium signaling and cancer

Laboratory of Protein Dynamics and Signaling

  • Allan Weissman - The ubiquitin system in normal cellular processes and disease
  • Jadranka Loncarek - Synchronization between cell- and centrosome- cycles and molecular mechanisms of centriole reduplication

Mouse Cancer Genetics Program

  • Shyam Sharan - Genomic instability and breast cancer susceptibility
  • Lino Tessarollo - Role of neurotrophins in development and disease
  • Peter Johnson - Transcriptional control of oncogene-induced senescence and tumorigenesis; spatial regulation of Ras signaling
  • Jonathan Keller - Molecular regulation of normal stem cell development
  • Kathrin Muegge - Epigenetic regulation of chromatin function and carcinogenesis