James P. Madigan, Ph.D.

James P. Madigan, Ph.D.
Staff Scientist

Team Member of:

Dr. Madigan recently came to the Hoang Lab, within the Thoracic Surgery Branch, as a Staff Scientist. He is working on identifying aberrant signaling pathways related to inflammation, believed to be involved in mesothelioma initiation and progression. Dr. Madigan is also working on the direct role(s) played by asbestos exposure to cell signaling pathways and the resulting changes in gene and protein expressions.

Areas of Expertise

1) cell signaling 2) signaling pathway analysis 3) protein-protein interactions 4) post-translational modifications 5) phospho-proteomics

Contact Info

James P. Madigan, Ph.D.
Center for Cancer Research
National Cancer Institute
Building 10-CRC, Room 3-5888
Bethesda, MD 20892-1201
Ph: 240-760-7216
james.madigan@nih.gov

Dr. Madigan recently came to the Hoang Lab, within the Thoracic Surgery Branch, as a Staff Scientist. He is working on identifying aberrant signaling pathways related to inflammation, believed to be involved in mesothelioma initiation and progression. Dr. Madigan is also working on the direct role(s) played by asbestos exposure to cell signaling pathways and the resulting changes in gene and protein expressions.

 

NIH Scientific Focus Areas:
Cancer Biology, Cell Biology, Molecular Biology and Biochemistry

Selected Key Publications

  1. Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y.
    J Biol Chem. 293(42): 16142-16159, 2018. [ Journal Article ]
  2. Hall MD, Telma KA, Chang KE, Lee TD, Madigan JP, Lloyd JR, Goldlust IS, Hoeschele JD, Gottesman MM.
    Cancer Res. 74(14): 3913-22, 2014. [ Journal Article ]
  3. Madigan JP, Bodemann BO, Brady DC, Dewar BJ, Keller PJ, Leitges M, Philips MR, Ridley AJ, Der CJ, Cox AD.
    Biochem J. 424(1): 153-61, 2009. [ Journal Article ]
  4. Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS.
    Proc Natl Acad Sci U S A. 102(36): 12879-84, 2005. [ Journal Article ]
  5. Madigan JP, Chotkowski HL, Glaser RL.
    Nucleic Acids Res. 30(17): 3698-705, 2002. [ Journal Article ]

Dr. Madigan received his undergraduate degree in Biology from the University at Buffalo (SUNY) in 1999. After graduation, he worked for several years at a biotech company before moving to the New York State Department of Health, in Albany, NY, studying histone post-translational modifications and chromatin remodeling. Dr. Madigan received his Ph.D. in molecular biology from the University of North Carolina at Chapel Hill in 2008, in the laboratory of Adrienne Cox. While at UNC-Chapel Hill, his research work centered around signaling mechanisms regulating the cellular localization and function of the Ras and Rho families of small GTPases. Dr. Madigan did postdoctoral work in the lab of Daniel Rosenberg, at the UCONN Health Center, dissecting the role of ceramide metabolism in resistance to oxaliplatin in colorectal cancer. Before recently coming to Dr. Hoang’s lab, Dr. Madigan spent 6 years in the laboratory of Michael Gottesman, within the Laboratory of Cell Biology at the NCI, identifying novel post-translational mechanisms regulating signaling pathways important for resistance to cancer chemotherapeutics.