Haobin Chen, M.D., Ph.D.

Haobin Chen, M.D., Ph.D.
Physician-Scientist Early Investigator

Dr. Chen's research focuses on developing novel epigenetic therapies for small cell lung cancer. He is board certified in internal medicine and board certified in medical oncology.

Areas of Expertise

1) lung cancer, 2) epigenetics, 3) molecular biology

Contact Info

Haobin Chen, M.D., Ph.D.
Center for Cancer Research
National Cancer Institute
Building 10-CRC, Room 3-5848
Bethesda, MD 20892
Ph: 240-760-6177

Small cell lung cancer (SCLC) is a deadly disease and represents 12-15% of all lung cancers. Little progress has been made in its treatment over the past 30 years. Some obstacles against progress are limited systemic treatment options and rapid development of drug resistance. There is an unmet need to understand resistance mechanisms and to develop novel therapies for SCLC.

Gene expression is controlled by epigenetic machinery in cells. Epigenetic therapy targets critical epigenetic machinery in cancer cells to restore normal gene expression and to stop cancer growth. BET bromodomain proteins are emerging epigenetic targets. The use of small molecule inhibitors to target this family of proteins has generated many promising results in liquid tumors, but this approach has not been tested in solid tumors. One of the focuses of my research is to identify which SCLC patients will benefit from this novel epigenetic therapy. The other focus of my research is to uncover drug resistance mechanism in SCLC by using a genome-wide high throughput screening approach.

NIH Scientific Focus Areas:
Cancer Biology, Chromosome Biology, Clinical Research, Genetics and Genomics, Molecular Biology and Biochemistry
  1. Thomas A, Redon CE, Sciuto L, Padiernos E, Ji J, Lee MJ, Yuno A, Lee S, Zhang Y, Tran L, Yutzy W, Rajan A, Guha U, Chen H, Hassan R, Alewine CC, Szabo E, Bates SE, Kinders RJ, Steinberg SM, Doroshow JH, Aladjem MI, Trepel JB, Pommier Y
    J Clin Oncol.. 36(16): 1594-1602, 2018. [ Journal Article ]
  2. Chen H, Giri NC, Zhang R, Yamane K, Zhang Y, Maroney M, Costa M
    J Biol Chem. 292(25): 10743, 2017. [ Journal Article ]
  3. Chen H, Zhang R, Kluz T, Costa M.
    Carcinogenesis. 31: 2136-2144, 2010. [ Journal Article ]
  4. Chen H, Ke Q, Kluz T, Yan Y, Costa M.
    Mol Cell Biol. 26: 3728-3737, 2006. [ Journal Article ]
  5. Chen H, Yan Y, Davidson TL, Shinkai Y, Costa M.
    Cancer Res. 66: 9009-9016, 2006. [ Journal Article ]

Dr. Chen received his M.D. and M.S. from Shanghai Medical University in China, and his Ph.D. degree from New York University (NYU). He was a research assistant professor at NYU for 4 years, and then completed an internal medicine residency at the Kingsbrook Jewish Medical Center in Brooklyn, NY. He joined the NCI Medical Oncology Branch as a clinical fellow in 2013. He is currently an assistant clinical investigator in the Thoracic and Gastrointestinal Oncology Branch.

Name Position
Anju Kumari Predoctoral Visting Fellow (Graduate Student)
Yan-Jin Liu Ph.D. Postdoctoral Fellow (Visiting)