Susan Bates, M.D.
Susan  Bates, M.D.
Senior Investigator
Head, Molecular Therapeutics Group

Dr. Bates' laboratory focuses on understanding multidrug resistance, which can be broadly defined as the simultaneous resistance to a variety of chemically unrelated chemotherapeutic agents. This multidrug resistance is present at the time of diagnosis in some tumor types, such as in renal cell carcinoma, or occurs following one or more courses of chemotherapy in more responsive diseases, such as breast cancer. The goal of Dr. Bates and her research team is to identify combination therapies that overcome drug resistance, or to identify antineoplastic agents that circumvent resistance. Studies conducted by this group have led to insights in cancer biology related to drug efflux pumps.

Areas of Expertise
1) multidrug resistance, 2) drug efflux pumps

Contact Info

Susan Bates, M.D.

Center for Cancer Research
National Cancer Institute

Building 10, Room 12N226
Bethesda, MD 20892-1906
301-402-0984

Reversal of Drug Resistance: Clinical and Laboratory Approaches

Achieving a clinical response to chemotherapy has proven to be simple in some diseases, and almost impossible in others. Our laboratory focus has been on understanding drug resistance, which can be broadly defined as the simultaneous resistance to a variety of chemically unrelated chemotherapeutic agents. This multidrug resistance is present at the time of diagnosis in some tumor types, such as in renal cell carcinoma, or occurs following one or more courses of chemotherapy in more responsive diseases, such as breast cancer.

Our goal is to identify combination therapies that overcome drug resistance, or to identify antineoplastic agents that circumvent resistance. Our laboratory studies have led to insights in cancer biology related to drug efflux pumps. Our group has studied ABCG2, a multidrug transporter able to confer resistance to a variety of chemotherapeutics. ABCG2 is interesting for its role in the blood brain barrier and in normal tissue protection.

Our group has been involved in the clinical and translational development of romidepsin, a histone deacetylase (HDAC) inhibitor, leading to our current area of focus on epigenetic therapies, and on the development of combination therapies to use with HDAC inhibitors. We have intensively studied the mechanism of action of HDAC inhibitors such as romidepsin (formerly depsipeptide), examining effects in both T-cell lymphoma and in solid tumor cells. We have established non-Pgp-expressing romidepsin-resistant cell lines in the laboratory with the goal of understanding mechanisms of resistance and then identifying other agents to be used in combination to overcome these resistance mechanisms. For example, overexpression of phospho-MEK in romidepsin-resistant cells appears to be a mechanism of resistance, and the addition of MEK inhibitors to romidepsin is an approach that we can take to improve outcome. Our goal is to translate this and other ideas to clinical trial.

Scientific Focus Areas:
Cell Biology, Chromosome Biology, Clinical Research, Molecular Pharmacology
  1. Luchenko VL, Litman T, Chakraborty AR, Heffner A, Devor C, Wilkerson J, Stein W, Robey RW, Bangiolo L, Levens D, Bates SE.
    Mol Oncol. [Epub ahead of print], 2014. [ Journal Article ]
  2. Chakraborty AR, Robey RW, Luchenko VL, Zhan Z, Piekarz RL, Gillet J, Kossenkov AV, Wilkerson J, Showe LC, Gottesman MM, Collie NL, Bates SE.
    Blood. 121: 4115-25, 2013. [ Journal Article ]
  3. Noonan AM, Eisch RA, Liewehr DJ, Sissung TM, Venzon DJ, Flagg TP, Haigney MC, Steinberg SM, Figg WD, Piekarz RL, Bates SE.
    Clin. Cancer Res.. 19: 3095-104, 2013. [ Journal Article ]
  4. Basseville A, Tamaki A, Ierano C, Trostel S, Ward Y, Robey RW, Hegde RS, Bates SE.
    Cancer Res. 72: 3642-51, 2012. [ Journal Article ]
  5. Piekarz RL, Frye R, Prince HM, Kirschbaum MH, Zain J, Allen SL, Jaffe ES, Ling A, Turner M, Peer CJ, Figg WD, Steinberg SM, Smith S, Joske D, Lewis I, Hutchins L, Craig M, Fojo AT, Wright JJ, Bates SE.
    Blood. 117:00:00: 5827-34, 2011. [ Journal Article ]

Dr. Susan Bates received her M.D. from the University of Arkansas School of Medicine. She completed her clinical training in internal medicine at Georgetown University in Washington, D.C., and in oncology at the NCI. Dr. Bates has held positions of increasing responsibility at the NCI, receiving tenure in 1992. Her interests range from clinical to laboratory studies on drug resistance in T-cell lymphomas, breast cancer and renal cell cancer. Her Molecular Therapeutics Section is dedicated to new drug development, and finding antineoplastic agents that, alone or in combination with other anticancer agents, improve cancer therapy.

Name Position
Julian Bahr Postbaccalaureate Fellow
Agnes Basseville Postdoctoral Fellow (Visiting)
Herbert Kotz M.D. Special Volunteer
Victoria Luchenko M.S. Research Biologist
Andrew Mcdonald B.S. Postbaccalaureate Fellow
Robert Robey Research Chemist
Wilfred Stein Bioinformatics Staff Scientist
Zhirong Zhan Research Biologist

Clinical Trials

Research

Reversal of Drug Resistance: Clinical and Laboratory Approaches

Achieving a clinical response to chemotherapy has proven to be simple in some diseases, and almost impossible in others. Our laboratory focus has been on understanding drug resistance, which can be broadly defined as the simultaneous resistance to a variety of chemically unrelated chemotherapeutic agents. This multidrug resistance is present at the time of diagnosis in some tumor types, such as in renal cell carcinoma, or occurs following one or more courses of chemotherapy in more responsive diseases, such as breast cancer.

Our goal is to identify combination therapies that overcome drug resistance, or to identify antineoplastic agents that circumvent resistance. Our laboratory studies have led to insights in cancer biology related to drug efflux pumps. Our group has studied ABCG2, a multidrug transporter able to confer resistance to a variety of chemotherapeutics. ABCG2 is interesting for its role in the blood brain barrier and in normal tissue protection.

Our group has been involved in the clinical and translational development of romidepsin, a histone deacetylase (HDAC) inhibitor, leading to our current area of focus on epigenetic therapies, and on the development of combination therapies to use with HDAC inhibitors. We have intensively studied the mechanism of action of HDAC inhibitors such as romidepsin (formerly depsipeptide), examining effects in both T-cell lymphoma and in solid tumor cells. We have established non-Pgp-expressing romidepsin-resistant cell lines in the laboratory with the goal of understanding mechanisms of resistance and then identifying other agents to be used in combination to overcome these resistance mechanisms. For example, overexpression of phospho-MEK in romidepsin-resistant cells appears to be a mechanism of resistance, and the addition of MEK inhibitors to romidepsin is an approach that we can take to improve outcome. Our goal is to translate this and other ideas to clinical trial.

Scientific Focus Areas:
Cell Biology, Chromosome Biology, Clinical Research, Molecular Pharmacology

Publications

  1. Luchenko VL, Litman T, Chakraborty AR, Heffner A, Devor C, Wilkerson J, Stein W, Robey RW, Bangiolo L, Levens D, Bates SE.
    Mol Oncol. [Epub ahead of print], 2014. [ Journal Article ]
  2. Chakraborty AR, Robey RW, Luchenko VL, Zhan Z, Piekarz RL, Gillet J, Kossenkov AV, Wilkerson J, Showe LC, Gottesman MM, Collie NL, Bates SE.
    Blood. 121: 4115-25, 2013. [ Journal Article ]
  3. Noonan AM, Eisch RA, Liewehr DJ, Sissung TM, Venzon DJ, Flagg TP, Haigney MC, Steinberg SM, Figg WD, Piekarz RL, Bates SE.
    Clin. Cancer Res.. 19: 3095-104, 2013. [ Journal Article ]
  4. Basseville A, Tamaki A, Ierano C, Trostel S, Ward Y, Robey RW, Hegde RS, Bates SE.
    Cancer Res. 72: 3642-51, 2012. [ Journal Article ]
  5. Piekarz RL, Frye R, Prince HM, Kirschbaum MH, Zain J, Allen SL, Jaffe ES, Ling A, Turner M, Peer CJ, Figg WD, Steinberg SM, Smith S, Joske D, Lewis I, Hutchins L, Craig M, Fojo AT, Wright JJ, Bates SE.
    Blood. 117:00:00: 5827-34, 2011. [ Journal Article ]

Biography

Dr. Susan Bates received her M.D. from the University of Arkansas School of Medicine. She completed her clinical training in internal medicine at Georgetown University in Washington, D.C., and in oncology at the NCI. Dr. Bates has held positions of increasing responsibility at the NCI, receiving tenure in 1992. Her interests range from clinical to laboratory studies on drug resistance in T-cell lymphomas, breast cancer and renal cell cancer. Her Molecular Therapeutics Section is dedicated to new drug development, and finding antineoplastic agents that, alone or in combination with other anticancer agents, improve cancer therapy.

Team

Name Position
Julian Bahr Postbaccalaureate Fellow
Agnes Basseville Postdoctoral Fellow (Visiting)
Herbert Kotz M.D. Special Volunteer
Victoria Luchenko M.S. Research Biologist
Andrew Mcdonald B.S. Postbaccalaureate Fellow
Robert Robey Research Chemist
Wilfred Stein Bioinformatics Staff Scientist
Zhirong Zhan Research Biologist