William G. Stetler-Stevenson, M.D., Ph.D.

William G. Stetler-Stevenson, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology


The spread or metastasis of cancer is ultimately responsible for most cancer deaths. New drugs employing unique mechanisms are needed to improve therapy of these advanced cancers. New biologic treatments based on functional changes in the extracellular matrix during cancer progression represent a novel approach. TIMPs are a small family of low molecular weight proteins first identified as endogenous metalloproteinase inhibitors. However, these proteins also modulate growth, migration and invasion of both normal and tumor cells. TIMP-2 inhibits tumor growth and metastasis in animal models independent of its protease inhibitor activity. TIMP-2 is under development as a new biologic therapy for cancer.

Areas of Expertise

Novel Biologic Therapy For Cancer


Selected Key Publications

An endogenous inhibitor of angiogenesis inversely correlates with side population phenotype and function in human lung cancer cells

Han H, Bourboulia D, Jensen-Taubman S, Isaac B, Wei B, Stetler-Stevenson WG.
Oncogene. 33: 1198-206, 2014. [ Journal Article ]

Antagonism of VEGF-A-induced increase in vascular permeability by an integrin a3ß1-Shp-1-cAMP/PKA pathway

Kim SH, Cho YR, Kim HJ, Oh JS, Ahn EK, Ko HJ, Hwang BJ, Lee SJ, Cho Y, Kim YK, Stetler-Stevenson WG, Seo DW.
Blood. 120: 4892-902, 2012. [ Journal Article ]

TIMP-2 mediated inhibition of angiogenesis: an MMP-independnet mechanism

Seo DW, Li H, Guedez L, Wingfield PT, Diaz T, Salloum R, Wei BY, Stetler-Stevenson WG.
Cell. 114: 171-180, 2003. [ Journal Article ]

Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5

Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V.
Science. 277: 225-8, 1997. [ Journal Article ]

Tumor cell interactions with the extracellular matrix during invasion and metastasis

Stetler-Stevenson WG, Aznavoorian S, Liotta LA.
Annu. Rev. Cell Biol. 9: 541-73, 1993. [ Journal Article ]

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Postbaccalaureate Fellow (CRTA)
Alex S. Kuznetsov
Postdoctoral Fellow (Visiting)
David Peeney, Ph.D.
Research Biologist
Beiyang Wei, M.S.


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