Scot Niglio, M.D., M.S.

Scot Niglio, M.D., M.S.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10, Room 12C342B
  • Bethesda, MD 20892
  • 240-858-7055
Genitourinary Malignancies Branch


Dr. Niglio is a medical oncologist who specializes in the care of patients with genitourinary cancers (prostate, kidney, bladder, testicular). His research focuses on using a person’s own immune system to fight cancer. He also develops treatments personalized to an individual patient’s cancer based on gene mutations and tumor characteristics.

Dr. Niglio is board certified in internal medicine and medical oncology.

Areas of Expertise

1) genitourinary cancers 2) bladder cancer 3) rare genitourinary cancers 4) immuno-oncology 5) immunotherapy 6) personalized medicine

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them.


Selected Key Publications

Programmed Death-1 or Programmed Death Ligand-1 Blockade in Patients with Platinum-resistant Metastatic Urothelial Cancer: A Systematic Review and Meta-analysis

Niglio SA, Jia R, Ji J, Ruder S, Patel VG, Martini A, Sfakianos JP, Marqueen KE, Waingankar N, Mehrazin R, Wiklund P, Oh WK, Mazumdar M, Ferket BS, Galsky MD.
European Urology. Epub ahead of print, 2019. [ Journal Article ]

Muscle-Invasive Bladder Cancer Undergoing Cystectomy in the United States

Marqueen KE, Waingankar N, Sfakianos JP, Mehrazin R, Niglio SA, Audenet F, Jia R, Mazumdar M, Ferket BS, Galsky MD.
JNCI Cancer Spectrum. 2(4): pky075, 2018. [ Journal Article ]

DNA Damage Response as Biomarkers Informing a Precision Medicine Approach to Bladder Cancer: What are the Next Steps?

Expert Review of Precision Medicine and Drug Development. 4: 7-9, 2019.

Effectiveness of Transurethral Resection plus Systemic Chemotherapy as Definitive Treatment for Muscle Invasive Bladder Cancer in Population Level Data

Audenet F, Waingankar N, Ferket BS, Niglio SA, Marqueen KE, Sfakianos JP, Galsky MD.
The Journal of Urology. 200(5): 996-1004, 2018. [ Journal Article ]

Precision Medicine for Relapsed Multiple Myeloma on the Basis of an Integrative Multiomics Approach

Laganà A, Beno I, Melnekoff D, Leshchenko V, Madduri D, Ramdas D, Sanchez L, Niglio S, Perumal D, Kidd BA, Miotto R, Shaknovich R, Chari A, Cho HJ, Barlogie B, Jagannath S, Dudley JT, Parekh S.
JCO Precision Oncology. Epub 2018 Aug 8, 2018. [ Journal Article ]