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Ronald E. Gress, M.D.

Ronald E. Gress, M.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 10 - Hatfield CRC, Room 3-3332
  • Bethesda, MD 20892-1203
  • 240-858-3030
  • 240-541-4566
  • gressr@mail.nih.gov

RESEARCH SUMMARY

Dr. Ronald Gress pursues investigation in basic, translational and clinical transplant immunology. His studies focus on T cell reconstitution in humans who have had depletion of T cell populations by chemotherapy. With collaborators, Dr. Gress introduced IL-7 into clinical trials. These studies allowed identification of T cell receptor repertoire repair by IL-7 – the basis of new strategies to repair repertoire defects and immune deficiency commonly associated with aging. As Chief of the Experimental Transplantation and Immunotherapy Branch, he oversees efforts to cure cancers through translational transplant therapies.

Areas of Expertise

1) T cells 2) immunology 3) immune reconstitution 4) hematopoietic stem cell transplantation 5) marrow transplant

Publications

Selected Key Publications

Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma

Brudno JN, Lam N, Vanasse D, Shen YW, Rose JJ, Rossi J, Xue A, Bot A, Scholler N, Mikkilineni L, Roschewski M, Dean R, Cachau R, Youkharibache P, Patel R, Hansen B, Stroncek DF, Rosenberg SA, Gress RE, Kochenderfer JN.
Nat Med. 26(2): 270-80, 2020. [ Journal Article ]

Immune Response Following Quadrivalent Human Papillomavirus Vaccination in Women After Hematopoietic Allogeneic Stem Cell Transplant: A Nonrandomized Clinical Trial

Stratton P, Battiwalla M, Tian X, Abdelazim S, Baird K, Barrett AJ, Cantilena CR, Childs RW, DeJesus J, Fitzhugh C, Fowler D, Gea-Banacloche J, Gress RE, Hickstein D, Hsieh M, Ito S, Kemp TJ, Khachikyan I, Merideth MA, Pavletic SZ, Quint W, Schiffman M, Scrivani C, Shanis D, Shenoy AG, Struijk L, Tisdale JF, Wagner S, Williams KM, Yu Q, Wood LV, Pinto LA.
JAMA Oncol. e196722, 2020. [ Journal Article ]

Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression

Wachsmuth LP, Patterson MT, Eckhaus MA, Venzon DJ, Gress RE, Kanakry CG.
J. Clin. Invest. 129(6): 2357-73, 2019. [ Journal Article ]

Imaging of subclinical haemopoiesis after stem-cell transplantation in patients with haematological malignancies: a prospective pilot study

Williams KM, Holter-Chakrabarty J, Lindenberg L, Duong Q, Vesely SK, Nguyen CT, Havlicek JP, Kurdziel K, Gea-Banacloche J, Lin FI, Avila DN, Selby G, Kanakry CG, Li S, Scordino T, Adler S, Bollard CM, Choyke P, Gress RE.
Lancet Haematol.. 5(1): e44-e52, 2018. [ Journal Article ]

T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

Ali SA, Shi V, Maric I, Wang M, Stroncek DF, Rose JJ, Brudno JN, Stetler-Stevenson M, Feldman SA, Hansen BG, Fellowes VS, Hakim FT, Gress RE, Kochenderfer JN.
Blood. 128(13): 1688-1700, 2016. [ Journal Article ]

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