Breadcrumb

Dr. Richard Hodes

Richard J. Hodes, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Experimental Immunology Branch

RESEARCH SUMMARY

Richard Hodes’ lab studies regulation of the development and function of the adaptive immune system. Ongoing work is focused on the role of T cell receptor and co-stimulatory signals in thymic development and T cell-dependent immune responses, and on the maintenance of chromosomal integrity and proliferative capacity during lymphocyte development and activation.

Areas of Expertise

1) thymus development, 2) T cell receptor, 3) costimulation, 4) tumor suppressor p53,
5) ataxia telangiectasia mutated

Publications

Selected Key Publications

Downmodulation of Tumor Suppressor p53 by T Cell Receptor Signaling Is Critical for Antigen-Specific CD4(+) T Cell Responses

Watanabe M, Moon KD, Vacchio MS, Hathcock KS, Hodes RJ.
Immunity. 40: 681-91, 2014. [ Journal Article ]

TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development

Jenkinson SR, Williams JA, Jeon H, Zhang J, Nitta T, Ohigashi I, Kruhlak M, Zuklys S, Sharrow S, Adams A, Granger L, Choi Y, Siebenlist U, Bishop GA, Hollander GA, Takahama Y, Hodes RJ.
Proc. Natl. Acad. Sci. U.S.A. 110: 21107-12, 2013. [ Journal Article ]

Identification of an alternative CTLA-4 ligand costimulatory for T cell activation

Hathcock KS, Laszlo G, Dickler HB, Bradshaw J, Linsley P, Hodes RJ.
Science. 262: 905-7, 1993. [ Journal Article ]

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function

Hathcock KS, Laszlo G, Pucillo C, Linsley P, Hodes RJ.
J. Exp. Med. 180: 631-40, 1994. [ Journal Article ]

Human naive and memory T lymphocytes differ in telomeric length and replicative potential

Weng NP, Levine BL, June CH, Hodes RJ.
Proc. Natl. Acad. Sci. U.S.A. 92: 11091-4, 1995. [ Journal Article ]

Job Vacancies

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Team

Postbaccalaureate Fellow (CRTA)
Sofia Io Celli
Research Chemist
Karen S. Hathcock, B.S.
Postdoctoral Fellow (Visiting)
Ying Lu, Ph.D.
Postdoctoral Fellow (Visiting)
Masashi Watanabe, Ph.D.
Postbaccalaureate Fellow (CRTA)
Max Xu
Postbaccalaureate Fellow (CRTA)
Ray Zhang