Lekha Mikkilineni, M.D.

Lekha Mikkilineni, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Surgery Branch


Dr. Mikkilineni treats patients with hematological malignancies (multiple myeloma, lymphoma and leukemia) with chimeric antigen receptor (CAR) T-cell therapy. Her research focuses on bringing novel multiple myeloma CAR T-cell therapies to patients through phase 1 clinical trials at the NIH Clinical Center. She is interested in patient outcomes with cellular therapies as well as understanding and managing the side effects associated with cellular therapy and immunotherapy.

Areas of Expertise

1) multiple myeloma 2) chimeric antigen receptor (CAR) T-cell therapy 3) blood cancer (including Hodgkin and non-Hodgkin lymphoma) 4) immunotherapy

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them.


Selected Key Publications

Chimeric antigen receptor T-cell therapies for multiple myeloma

Mikkilineni L, Kochenderfer JN.
Blood. 130(24): 2594-2602, 2017. [ Journal Article ]

T Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma

1: Brudno JN, Maric I, Hartman SD, Rose JJ, Wang M, Lam N, Stetler-Stevenson M, Salem D, Yuan C, Pavletic S, Kanakry JA, Ali SA, Mikkilineni L, Feldman SA, Stroncek DF, Hansen BG, Lawrence J, Patel R, Hakim F, Gress RE, Kochenderfer JN.
J Clin Oncol. 6(22): 2267-2280, 2018. [ Journal Article ]

Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment

Mikkilineni L, Whitaker-Menezes D, Domingo-Vidal M, Sprandio J, Avena P, Cotzia P, Dulau-Florea A, Gong J, Uppal G, Zhan T, Leiby B, Lin Z, Pro B, Sotgia F, Lisanti MP, Martinez-Outschoorn U.
Semin Oncol. 44(3): 218-225, 2017. [ Journal Article ]

Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma

Brudno JN, Lam N, Vanasse D, Shen YW, Rose JJ, Rossi J, Xue A, Bot A, Scholler N, Mikkilineni L, Roschewski M, Dean R, Cachau R, Youkharibache P, Patel R, Hansen B, Stroncek DF, Rosenberg SA, Gress RE, Kochenderfer JN.
Nat Med. 26(2): 270-280, 2020. [ Journal Article ]