Jianbo  Chen, Ph.D.

Jianbo Chen, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Chen is interested in understanding the mechanisms of virus replication and interactions of viruses with host cells. He has worked with diverse virus-host systems, from positive-strand RNA viruses to retroviruses and from yeast and plants to mammalian hosts. He is currently studying retroviral RNA trafficking, RNA packaging, and virus assembly by using live-cell imaging with advanced microscopy and image analysis.

Areas of Expertise

1) cellular and molecular biology 2) RNA viruses and retroviruses 3) light microscopy 4) live-cell imaging 5) image analysis


Selected Key Publications

High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis

Chen J, Nikolaitchik O, Singh J, Wright A, Bencsics CE, Coffin JM, Ni N, Lockett S, Pathak VK, Hu WS.
Proc. Natl. Acad. Sci. U.S.A. 106: 13535-40, 2009. [ Journal Article ]

Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor

Chen J, Dang Q, Unutmaz D, Pathak VK, Maldarelli F, Powell D, Hu WS.
J. Virol. 79: 4140-9, 2005. [ Journal Article ]

Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways

Dang Q, Chen J, Unutmaz D, Coffin JM, Pathak VK, Powell D, KewalRamani VN, Maldarelli F, Hu WS.
Proc. Natl. Acad. Sci. U.S.A. 101: 632-7, 2004. [ Journal Article ]

A positive-strand RNA virus replication complex parallels form and function of retrovirus capsids

Schwartz M, Chen J, Janda M, Sullivan M, den Boon J, Ahlquist P.
Mol. Cell. 9: 505-14, 2002. [ Journal Article ]