Jianbo Chen, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 535, Room 324
- Frederick, MD 21702-1201
- 301-846-1841
- chenjia@mail.nih.gov
RESEARCH SUMMARY
Dr. Chen is interested in understanding the mechanisms of virus replication and interactions of viruses with host cells. He has worked with diverse virus-host systems, from positive-strand RNA viruses to retroviruses and from yeast and plants to mammalian hosts. He is currently studying retroviral RNA trafficking, RNA packaging, and virus assembly by using live-cell imaging with advanced microscopy and image analysis.
Areas of Expertise
1) cellular and molecular biology 2) RNA viruses and retroviruses 3) light microscopy 4) live-cell imaging 5) image analysis
Jianbo Chen, Ph.D.
Research
Live-Cell Imaging and Single Molecule Tracking to Study HIV-1 Replication
I am currently studying retroviral RNA trafficking, RNA packaging, and virus assembly in human immunodeficiency virus type 1 (HIV-1) using live-cell imaging with advanced microscopy and image analysis.
Publications
High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis
Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection: preference in virus entry is important but is not the sole factor
Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways
A positive-strand RNA virus replication complex parallels form and function of retrovirus capsids
Brome mosaic virus polymerase-like protein 2a is directed to the endoplasmic reticulum by helicase-like viral protein 1a
Biography
Jianbo Chen, Ph.D.
Dr. Jianbo Chen obtained his Ph.D. in virology at Kagoshima University (Japan) in 1997. He joined Dr. Paul Ahlquist's laboratory in 1997 at the Institute for Molecular Virology, University of Wisconsin-Madison, where he studied RNA replication and translation of brome mosaic virus. Dr. Chen joined the HIV Drug Resistance Program, National Cancer Institute, as a research fellow in 2002. He was promoted to a staff scientist in 2005.