National Cancer Institute - Cancer.gov

Jane B.Neckers

Jane B. Neckers

  • Center for Cancer Research
  • National Cancer Institute
Developmental Therapeutics Branch

RESEARCH SUMMARY

Jane Neckers came to the NCI from the Laboratory of Preclinical Pharmacology, National Institute of Mental Health, where she identified posttranslational modification of glycoprotein hormones by ADP-ribosylation. Since then she has held positions of increasing responsibility in the former Clinical Pharmacology Branch and Medicine Branch. She is the author of five issued and pending patents in new drug development and is the recipient of a Federal Technology Transfer Award. Her interests are focused on the new therapeutic opportunities provided by molecular dissection of aberrant tumor cell signaling pathways.

Areas of Expertise

1) drug development

Publications

Selected Publications

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

Beebe K, Mollapour M, Scroggins B, Prodromou C, Xu W, Tokita M, Taldone T, Pullen L, Zierer BK, Lee MJ, Trepel J, Buchner J, Bolon D, Chiosis G, Neckers L.
Oncotarget. 4: 1065-74, 2013. [ Journal Article ]

A phase II trial of pan-KIR2D blockade with IPH2101 in smoldering multiple myeloma

Korde N, Carlsten M, Lee MJ, Minter A, Tan E, Kwok M, Manasanch E, Bhutani M, Tageja N, Roschewski M, Zingone A, Costello R, Mulquin M, Zuchlinski D, Maric I, Calvo KR, Braylan R, Tembhare P, Yuan C, Stetler-Stevenson M, Trepel J, Childs R, Landgren O.
Haematologica. 99: e81-3, 2014. [ Journal Article ]

Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors

Mollapour M, Bourboulia D, Beebe K, Woodford MR, Polier S, Hoang A, Chelluri R, Li Y, Guo A, Lee MJ, Fotooh-Abadi E, Khan S, Prince T, Miyajima N, Yoshida S, Tsutsumi S, Xu W, Panaretou B, Stetler-Stevenson WG, Bratslavsky G, Trepel JB, Prodromou C, Neckers L.
Mol. Cell. 53: 317-29, 2014. [ Journal Article ]

Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity

Walton-Diaz A, Khan S, Bourboulia D, Trepel JB, Neckers L, Mollapour M.
Future Med Chem. 5: 1059-71, 2013. [ Journal Article ]

Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

Yoshida S, Tsutsumi S, Muhlebach G, Sourbier C, Lee MJ, Lee S, Vartholomaiou E, Tatokoro M, Beebe K, Miyajima N, Mohney RP, Chen Y, Hasumi H, Xu W, Fukushima H, Nakamura K, Koga F, Kihara K, Trepel J, Picard D, Neckers L.
Proc. Natl. Acad. Sci. U.S.A.. 110: E1604-12, 2013. [ Journal Article ]

Team

Postbaccalaureate Fellow (CRTA)
Jonathan Baker
Postbaccalaureate Fellow (CRTA)
Leah N. Franklin
Research Chemist
Sunmin Lee, Ph.D.
Postdoctoral Fellow (CRTA)
Shraddha Rastogi , Ph.D.