David M. Sturgill, Ph.D.

David M. Sturgill, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Sturgill is a computational biologist with a primary interest in understanding genome function and gene regulation. Through integrative analysis of high-throughput datasets, and applying novel statistical strategies, Dr. Sturgill has made important contributions to the fields of genomics and transcriptomics.

Areas of Expertise

1) bioinformatics, 2) alternative splicing, 3) gene expression, 4) genomics,
5) computational biology


Selected Publications

TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing

Marina RJ*, Sturgill D*, Bailly MA*, Thenoz M*, Varma G, Prigge MF, Nanan KK, Shukla S, Haque N, Oberdoerffer S.
EMBO J. 35(3: 335-55, 2016. [ Journal Article ]

Comparative validation of the D. melanogaster modENCODE transcriptome annotation

Chen ZX*, Sturgill D*, Qu J, Jiang H, Park S, et al.
Genome Res. 24(7): 1209-23, 2014. [ Journal Article ]

Design of RNA splicing analysis null models for post hoc filtering of Drosophila head RNA-Seq data with the splicing analysis kit (Spanki)

Sturgill D, Malone JH, Sun X, Smith HE, Rabinow L, Samson ML, Oliver B.
BMC Bioinformatics. 14: 320, 2013. [ Journal Article ]

Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster

Deng X, Hiatt JB, Nguyen DK, Ercan S, Sturgill D, Hillier LW, Schlesinger F, Davis CA, Reinke VJ, Gingeras TR, Shendure J, Waterston RH, Oliver B, Lieb JD, Disteche CM.
Nat Genet. 43(12): 1179-85, 2011. [ Journal Article ]

Demasculinization of X chromosomes in the Drosophila genus

Sturgill D, Zhang Y, Parisi M, Oliver B.
Nature. 450(7167): 238-41, 2007. [ Journal Article ]