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Cristina  Bergamaschi, Ph.D.

Cristina Bergamaschi, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Vaccine Branch

RESEARCH SUMMARY

Dr. Bergamaschi's research focus is on the regulation of immunity in cancer and infectious disease. Her main project investigates the molecular biology of cytokines, in particular interleukin-15 (IL-15), and their role in lymphocyte homeostasis, with the ultimate goal of developing improved vaccine and immune therapy strategies for clinical applications.

Areas of Expertise

1) regulation of immunity 2) cytokines 3) IL-15

Publications

Selected Key Publications

Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity

Bergamaschi C, Rosati M, Jalah R, Valentin A, Kulkarni V, Alicea C, Zhang GM, Patel V, Felber BK, Pavlakis GN.
J Biol Chem. 283: 4189-99, 2008. [ Journal Article ]

Secretion and biological activity of short signal peptide IL-15 is chaperoned by IL-15 receptor alpha in vivo

Bergamaschi C, Jalah R, Kulkarni V, Rosati M, Zhang GM, Alicea C, Zolotukhin AS, Felber BK, Pavlakis GN.
J Immunol. 183: 3064-72, 2009. [ Journal Article ]

DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge

Rosati M, Bergamaschi C, Valentin A, Kulkarni V, Jalah R, Alicea C, Patel V, von Gegerfelt AS, Montefiori DC, Venzon DJ, Khan AS, Draghia-Akli R, Van Rompay KK, Felber BK, Pavlakis GN.
Proc Natl Acad Sci USA. 106: 15831-6, 2009. [ Journal Article ]

Circulating IL-15 exists as heterodimeric complex with soluble IL-15Ralpha in human and mouse serum

Bergamaschi C, Bear J, Rosati M, Beach RK, Alicea C, Sowder R, Chertova E, Rosenberg SA, Felber BK, Pavlakis GN.
Blood. 120: e1-8, 2012. [ Journal Article ]

Characterization and favorable in vivo properties of heterodimeric soluble IL-15/IL-15Rα cytokine compared to IL-15 monomer

Chertova E, Bergamaschi C, Chertov O, Sowder R, Bear J, Roser JD, Beach RK, Lifson JD, Felber BK, Pavlakis GN.
J Biol Chem. 288: 18093-103, 2013. [ Journal Article ]