Cristina Bergamaschi, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 535, Room 226A
- Frederick, MD 21702
- 301-846-1856
- cristina.bergamaschi@nih.gov
RESEARCH SUMMARY
Dr. Bergamaschi's research focus is on the regulation of immunity in cancer and infectious disease. Her main project investigates the molecular biology of cytokines, in particular interleukin-15 (IL-15), and their role in lymphocyte homeostasis, with the ultimate goal of developing improved vaccine and immune therapy strategies for clinical applications.
Areas of Expertise
1) regulation of immunity 2) cytokines 3) IL-15
Cristina Bergamaschi, Ph.D.
Research
Dr. Bergamaschi's research focuses on the regulation of immunity in cancer and infectious disease. Her main project investigates the molecular biology of cytokines, in particular interleukin-15 (IL-15), and their role in lymphocyte homeostasis, with the ultimate goal of developing improved vaccine and immune therapy strategies for clinical applications.
Publications
Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity
Secretion and biological activity of short signal peptide IL-15 is chaperoned by IL-15 receptor alpha in vivo
DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge
Circulating IL-15 exists as heterodimeric complex with soluble IL-15Ralpha in human and mouse serum
Characterization and favorable in vivo properties of heterodimeric soluble IL-15/IL-15Rα cytokine compared to IL-15 monomer
Biography
Cristina Bergamaschi, Ph.D.
Dr. Cristina Bergamaschi received her Ph.D. in molecular medicine specializing in immunology from the University of Milan, Italy, in 2008. After postdoctoral training in the Human Retrovirus Section, Vaccine Branch, NCI, Dr. Bergamaschi joined the Human Retrovirus Pathogenesis Section, Vaccine Branch, as a staff scientist in 2012.