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Chyi-Chia Richard Lee, M.D., Ph.D.

Chyi-Chia Richard Lee, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology

RESEARCH SUMMARY

Dr. Lee completed his residency training in Anatomic and Clinical Pathology at the University of Pennsylvania Medical Center. He also completed a Surgical Pathology Fellowship at the University of Pennsylvania and a Dermatopathology Fellowship at the Baylor College of Medicine. He is board certified in Anatomic and Clinical Pathology and in Dermatopathology. He joined NCI as a Staff Clinician in 2006. His research experience includes a 2 year post-doctoral research fellowship at the Johns Hopkins University School of Medicine under the mentorship of Professor David Sidransky. He is licensed to practice medicine in the States of Arizona, California, Delaware, Florida, Maryland, New Jersey, Pennsylvania, Texas, Virginia, Washington, and the District of Columbia.

Areas of Expertise

1) Dermatopathology, 2) Surgical Pathology, 3) Anatomic and Clinical Pathology

Publications

Selected Publications

Early-onset stroke and vasculopathy associated with mutations in ADA2

Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, Stone DL, Chae JJ, Rosenzweig SD, Bishop K, Barron KS, Kuehn HS, Hoffmann P, Negro A, Tsai WL, Cowen EW, Pei W, Milner JD, Silvin C, Heller T, Chin DT, Patronas NJ, Barber JS, Lee CC, Wood GM, Ling A, Kelly SJ, Kleiner DE, Mullikin JC, Ganson NJ, Kong HH, Hambleton S, Candotti F, Quezado MM, Calvo KR, Alao H, Barham BK, Jones A, Meschia JF, Worrall BB, Kasner SE, Rich SS, Goldbach-Mansky R, Abinun M, Chalom E, Gotte AC, Punaro M, Pascual V, Verbsky JW, Torgerson TR, Singer NG, Gershon TR, Ozen S, Karadag O, Fleisher TA, Remmers EF
N Engl J Med.. 370/10: 911-20, 2014. [ Journal Article ]

Activated STING in a vascular and pulmonary syndrome

Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Sanchez GAM, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CR, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C, Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z
N Engl J Med.. 371/6: 507-518, 2014. [ Journal Article ]

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgård U, Cowen EW, Pham TH, Booty M, Estes JD, Sandler NG, Plass N, Stone DL, Turner ML, Hill S, Butman JA, Schneider R, Babyn P, El-Shanti HI, Pope E, Barron K, Bing X, Laurence A, Lee CC, Chapelle D, Clarke GI, Ohson K, Nicholson M, Gadina M, Yang B, Korman BD, Gregersen PK, van Hagen PM, Hak AE, Huizing M, Rahman P, Douek DC, Remmers EF, Kastner DL, Goldbach-Mansky R
N Engl J Med.. 360/23: 2426-37, 2009. [ Journal Article ]

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease

David B Beck, Marcela A Ferrada , Keith A Sikora , Amanda K Ombrello , Jason C Collins, Wuhong Pei , Nicholas Balanda , Daron L Ross , Daniela Ospina Cardona , Zhijie Wu , Bhavisha Patel, Kalpana Manthiram , Emma M Groarke , Fernanda Gutierrez-Rodrigues, Patrycja Hoffmann , Sofia Rosenzweig, Shuichiro Nakabo , Laura W Dillon, Christopher S Hourigan, Wanxia L Tsai , Sarthak Gupta , Carmelo Carmona-Rivera, Anthony J Asmar , Lisha Xu, Hirotsugu Oda, Wendy Goodspeed , Karyl S Barron, Michele Nehrebecky,
NEJM. 2020. [ Journal Article ]

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

Steven E. Boyden, Ph.D., Avanti Desai, M.S., Glenn Cruse, Ph.D., Michael L. Young, M.S.P.H., Hyejeong C. Bolan, M.S.N., Linda M. Scott, M.S.N., A. Robin Eisch, R.N., R. Daniel Long, B.S., B.A., Chyi-Chia R. Lee, M.D., Ph.D., Colleen L. Satorius, B.S., Andrew J. Pakstis, Ph.D., Ana Olivera, Ph.D., James C. Mullikin, Ph.D., Eliane Chouery, Ph.D., André Mégarbané, M.D., Ph.D., Myrna Medlej-Hashim, Ph.D., Kenneth K. Kidd, Ph.D., Daniel L. Kastner, M.D., Ph.D., Dean D. Metcalfe, M.D., and Hirsh D. Komarow, M.D.
N Engl J Med.. 374/7: 656-663, 2016. [ Journal Article ]