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Christian S. Hinrichs, M.D.

Christian S. Hinrichs, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Immuno-Oncology

RESEARCH SUMMARY

Dr. Hinrichs left CCR in January 2021.  He researched immunotherapy for HPV+ cancers, which include cervical, oropharyngeal, anal, vulvar, vaginal, and penile malignancies. Dr. Hinrichs discovered personalized cellular and gene therapies for HPV+ cancers. His laboratory studied why these treatments work in some patients and not in others and used what was learned to innovate more effective therapies.

Areas of Expertise

1) immunotherapy 2) cell therapy 3) human papillomavirus 4) cervical cancer 5) oropharyngeal cancer 6) anal cancer

Publications

Selected Recent Publications

T-Cell Receptor Gene Therapy for Human Papillomavirus-Associated Epithelial Cancers: A First-in-Human, Phase I/II Study

Doran SL, Stevanović S, Adhikary S, Gartner JJ, Jia L, Kwong MLM, Faquin WC, Hewitt SM, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS.
J Clin Oncol. 37(30): 2759-68, 2019. [ Journal Article ]

A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial Cancers

Stevanović S, Helman SR, Wunderlich JR, Langhan MM, Doran SL, Kwong MLM, Somerville RPT, Klebanoff CA, Kammula US, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS.
Clin Cancer Res. 25(5): 1486-93, 2019. [ Journal Article ]

Cell-based molecularly targeted therapy: targeting oncoproteins with T cell receptor gene therapy

Hinrichs CS
J Clin Invest. 128(4): 1261-63, 2018. [ Journal Article ]

Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

Stevanović S, Pasetto A, Helman SR, Gartner JJ, Prickett TD, Howie B, Robins HS, Robbins PF, Klebanoff CA, Rosenberg SA, Hinrichs CS.
Science. 356(6334): 200-205, 2017. [ Journal Article ]

Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6.

Draper LM, Kwong ML, Gros A, Stevanovic S, Tran E, Kerkar S, Raffeld M, Rosenberg SA, Hinrichs CS
Clin Cancer Res. 21(19): 4431-9, 2015. [ Journal Article ]