Breadcrumb

Brid M. Ryan, Ph.D., M.P.H.

Brid M. Ryan, Ph.D., M.P.H.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Ryan left CCR in April 2021. Dr. Ryan was among the first to demonstrate asymmetric division of DNA in cancer. This process is thought to underpin how tumors self-renew and regenerate. Her studies examined the roles of the tumor microenvironment and p53 in regulating this process in lung cancer. Her lab oversaw an integrative and translational approach to lung cancer research, examining the genetic, environmental, and biological contributions to racial disparities in lung cancer incidence. Her research program also developed biomarkers for the early detection of lung cancer.

Areas of Expertise

1) lung cancer 2) asymmetric division 3) molecular epidemiology 4) health disparities 5) small non-coding RNAs 6) cancer biomarkers

Publications

Selected Key Publications

Racial and Ethnic Differences in the Relationship between Aspirin Use and Non-Small Cell Lung Cancer Risk and Survival.

Erickson P, Gardner LD, Loffredo CA, St George DM, Bowman ED, Deepak J, Mitchell K, Meaney CL, Langenberg P, Bernat DH, Amr S, Ryan BM.
Cancer Epidemiol Biomarkers Prev. Aug 31. doi: 10.1158/1055-9965: 2018.

Comparative Transcriptome Profiling Reveals Coding and Noncoding RNA Differences in NSCLC from African Americans and European Americans.

Mitchell KA, Zingone A, Toulabi L, Boeckelman J, Ryan BM.
Clin Cancer Res. Dec 1;23(23): 7412-7425, 2017. [ Journal Article ]

A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood.

Robles AI, Yang P, Jen J, McClary AC, Calhoun K, Bowman ED, Vähäkangas K, Greathouse KL, Wang Y, Olivo-Marston S, Wenzlaff AS, Deng B, Schwartz AG, Ryan BM.
Cancer Prev Res . Dec;7(12):: 1210-8, 2014. [ Journal Article ]

Lung cancer health disparities

Ryan BM
Carcinogenesis. May 28;39(6): 741-751, 2018. [ Journal Article ]

Microenvironmental modulation of asymmetric cell division in human lung cancer cells

Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC.
Proc. Natl. Acad. Sci. U.S.A. 107: 2195-200, 2010. [ Journal Article ]