Asaf Shilo headshot

Asaf Shilo, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Asaf Shilo is a Staff Scientist in Dr. Tom Misteli's Lab. His work focuses on regulation of Alternative Splicing, using molecular biology, biochemistry and imaging-based methods.

Areas of Expertise

1) Alternative Splicing, 2) RNA, 3) Regulation of Gene Expression


Selected Recent Publications

Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson-Gilford progeria syndrome

Puttaraju M, Jackson M, Klein S, Shilo A, Bennett CF, Gordon L, Rigo F, Misteli T.
Nat Med. 27: 526–535, 2021.
Full-Text Article
[ Journal Article ]

2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels

Neumann-Raizel H, Shilo A, Lev S, Mogilevsky M, Katz B, Shneor D, Shaul YD, Leffler A, Gabizon A, Karni R, Honigman A, Binshtok AM.
Front Pharmacol. 10: 1198, 2019.
Full-Text Article
[ Journal Article ]

Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome

Shilo A, Tosto FA, Rausch JW, Le Grice SFJ, Misteli T
Nucleic Acids Res. 47(11): 5922–5935, 2019.
Full-Text Article
[ Journal Article ]

Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation

Malakar P, Shilo A, Mogilevsky A, Stein I, Pikarsky E, Nevo Y, Benyamini H, Elgavish S, Zong X, Prasanth KV, Karni R.
Cancer Res. 77(5): 1155-1167, 2017.
Full-Text Article
[ Journal Article ]

A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1

Hollander, D. Donyo, M. Atias, N. Mekahel, K. Melamed, Z. Yannai, S. Lev-Maor, G. Shilo, A. Schwartz, S. Barshack, I. Sharan, R. and Ast, G
Genome Res. 26(4): 541-53, 2016.
Full-Text Article
[ Journal Article ]