CONTRIBUTORS Pamela Beltowski Brenda Boersma-Maland Chabelis Byamana Li Gwatkin Michelle Hampson Allen Kane Julia Langer Jasmine Lee Joseph Meyer Jennifer Michalowski Mike Miller Gabrielle Stearns CENTER FOR CANCER RESEARCH The Nation’s Cancer Center The Center for Cancer Research (CCR) is the largest division of the National Cancer Institute’s intramural research program with nearly 250 basic and clinical research groups located on two campuses just outside of Washington, D.C. The CCR is home to an extraordinary group of scientists and clinicians exploring the cutting edge of cancer and HIV/AIDS research. Our scientists work on a wide spectrum of biological and biomedical problems that range from understanding genes, proteins and cellular pathways to using artificial intelligence and machine learning to explore large cancer datasets, developing novel methods for drug discovery, inventing biomedical devices and technology and creating innovative ways to treat patients. Our scientists enjoy complete intellectual freedom and are expected to creatively and innovatively explore the most important questions in the field of cancer research and treatment. We support projects over a long time horizon, allowing our investigators to pursue some of the most difficult, high-risk problems in the field, and we are always on the lookout for new challenges and the most pressing problems in modern cancer research. The success of CCR is grounded in an exceptionally strong discovery research program that provides the foundation for the seamless translation of insights into basic cellular and molecular processes to clinical applications and patient care. Examples of our success are the development of groundbreaking immunotherapy approaches, HIV/AIDS testing and the creation of a human papillomavirus vaccine. The CCR is a unique place of science where we combine diverse expertise with the freedom to thoroughly pursue the most pressing questions in cancer biology and treatment. For more about our science, our training programs and our clinical trials, visit ccr.cancer.gov. Inside the NIH Clinical Center, all types of activities take place. The building is filled with everything from operating rooms and patient beds to laboratories buzzing with activity as represented on this year’s cover. The work we do at CCR — where findings from a lab inform patient studies and treatments, and the results of patient studies inform the next batch of laboratory investigations — is the epitome of benchto-bedside and back. Like the puzzle pieces seen here, they all connect to create the cancer medicines of tomorrow. Credit: SPGM, FNL, NCI, NIH The MISSION of CCR is to improve the lives of all cancer patients by solving important, challenging and neglected problems in cancer research and patient care through: • A world-leading basic, translational and clinical research and patient care program • An institutional focus on high-risk and long-term projects, unmet needs and pursuit of unexplored ideas • Research to eliminate cancer health disparities • Leadership and coordination of national disease networks and development of technology resources for the cancer community • Partnerships with academic institutions, commercial entities and patient advocacy groups • Training of the next generation of a diverse and inclusive biomedical workforce
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