CCR Milestones - 2019

On the cover, hairy cell leukemia cells (purple) are shown under attack by the cancer drug moxetumomab pasudotox, or Moxe (orange dots). In the foreground, Moxe, which is composed of amonoclonal antibody (gold) attached to a toxin (red), binds to a receptor on a cancer cell’s surface (purple, foreground). Once it binds to the cancer cells, Moxe can deliver its attached toxin and induce cancer cell death, as shown in the lower right. Credit: Veronica Falconieri Hays, Falconieri Visuals As part of the federally funded National Cancer Institute (NCI), the Center for Cancer Research (CCR) is the nation’s cancer center. Located in the suburbs of Washington, D.C., our scientists are unlocking the mysteries of cancer and discovering new ways to prevent, diagnose and treat it. The CCR collaborates with academic and commercial partners and advocacy groups across the world in efforts to find treatments and cures for cancer through basic, clinical and translational research. Our physician-researchers translate these discoveries from the lab to the clinic, and we treat thousands of people from around the country every year with novel therapies through our clinical trials program at the National Institutes of Health (NIH) Clinical Center. For more about our science, our training programs and our clinical trials, visit ccr.cancer.gov . Contributors: Brenda Boersma-Maland Chia-Chi Charlie Chang Veronica Falconieri Hays Li Gwatkin Abbie Harrison Allen Kane Joseph Meyer Jennifer Michalowski Mike Miller Melissa Pandika Lianne Priede THE NATION’S CANCER CENTER CENTER FOR CANCER RESEARCH