Shree Ram  Singh, Ph.D.
Shree Ram Singh, Ph.D.
Staff Scientist

Center for Cancer Research
National Cancer Institute

Building 560, Room 12-15
Frederick, MD 21702-1201
301-846-7331

Stem cells have the inherent abilities to self-renew and to differentiate into several specialized cell types as well as control the maintenance of our tissues and organs. Failure of such maintenance results in several degenerative diseases and cancer. Stem cells have recently attracted significant attention mainly because of their potential medical benefits in the fields of therapeutic cloning and regenerative medicine. Our current research directed toward understanding the molecular genetic mechanism by which stem cells regulate tissues homeostasis, regeneration, and tumorigenesis. We are utilizing Drosophila and mouse models to understand the above mechanisms. Specifically, we are using adult testis, kidney and gastrointestinal tissues to characterize the genes/signaling pathways regulate stem cell behavior and tumor formation. The knowledge gained from stem cells regulation in Drosophila and mouse models will provide a basis to understand how human adult stem cells response during normal and pathological conditions.

Areas of Expertise
stem cells

Stem cells have the inherent abilities to self-renew and to differentiate into several specialized cell types as well as control the maintenance of our tissues and organs. Failure of such maintenance results in several degenerative diseases and cancer. Stem cells have recently attracted significant attention mainly because of their potential medical benefits in the fields of therapeutic cloning and regenerative medicine. Our current research directed toward understanding the molecular genetic mechanism by which stem cells regulate tissues homeostasis, regeneration, and tumorigenesis. We are utilizing Drosophila and mouse models to understand the above mechanisms. Specifically, we are using adult testis, kidney and gastrointestinal tissues to characterize the genes/signaling pathways regulate stem cell behavior and tumor formation. The knowledge gained from stem cells regulation in Drosophila and mouse models will provide a basis to understand how human adult stem cells response during normal and pathological conditions.

Selected Publications
  1. Singh SR, Liu W, Hou SX.
    Cell Stem Cell. 1: 191-203, 2007. [ Journal Article ]
  2. Singh SR, Zhen W, Zheng Z, Wang H, Oh SW, Liu W, Zbar B, Schmidt LS, Hou SX.
    Oncogene. 25: 5933-41, 2006. [ Journal Article ]
  3. Wang H, Singh SR, Zheng Z, Oh SW, Chen X, Edwards K, Hou SX.
    Dev. Cell. 10: 117-26, 2006. [ Journal Article ]
  4. Singh SR, Zeng X, Zheng Z, Hou SX.
    Cell Cycle. 10: 1109-20, 2011. [ Journal Article ]
  5. Singh SR, Mishra MK, Kango-Singh M, Hou SX.
    Methods Mol. Biol.. 879: 47-69, 2012. [ Journal Article ]

Dr. Shree Ram Singh obtained his Ph.D. in genetics from Department of Zoology, Banaras Hindu University, India in 2001. He was guest scientist at the Department of Molecular Cell Biology, Biocenter, Johann Wolfgang Goethe University Frankfurt, Germany in 1998 and in a UNESCO-BAC fellowship at the Department of Plant Molecular Biology Biocenter, Johann Wolfgang Goethe University Frankfurt, Germany in 2001. He pursued Post-doctoral research studies at University of Haifa, Israel and at National Cancer Institute at Frederick. Since 2011, he is a Staff Scientist at National Cancer Institute at Frederick.

Summary

Stem cells have the inherent abilities to self-renew and to differentiate into several specialized cell types as well as control the maintenance of our tissues and organs. Failure of such maintenance results in several degenerative diseases and cancer. Stem cells have recently attracted significant attention mainly because of their potential medical benefits in the fields of therapeutic cloning and regenerative medicine. Our current research directed toward understanding the molecular genetic mechanism by which stem cells regulate tissues homeostasis, regeneration, and tumorigenesis. We are utilizing Drosophila and mouse models to understand the above mechanisms. Specifically, we are using adult testis, kidney and gastrointestinal tissues to characterize the genes/signaling pathways regulate stem cell behavior and tumor formation. The knowledge gained from stem cells regulation in Drosophila and mouse models will provide a basis to understand how human adult stem cells response during normal and pathological conditions.

Areas of Expertise
stem cells

Research

Stem cells have the inherent abilities to self-renew and to differentiate into several specialized cell types as well as control the maintenance of our tissues and organs. Failure of such maintenance results in several degenerative diseases and cancer. Stem cells have recently attracted significant attention mainly because of their potential medical benefits in the fields of therapeutic cloning and regenerative medicine. Our current research directed toward understanding the molecular genetic mechanism by which stem cells regulate tissues homeostasis, regeneration, and tumorigenesis. We are utilizing Drosophila and mouse models to understand the above mechanisms. Specifically, we are using adult testis, kidney and gastrointestinal tissues to characterize the genes/signaling pathways regulate stem cell behavior and tumor formation. The knowledge gained from stem cells regulation in Drosophila and mouse models will provide a basis to understand how human adult stem cells response during normal and pathological conditions.

Publications

Selected Publications
  1. Singh SR, Liu W, Hou SX.
    Cell Stem Cell. 1: 191-203, 2007. [ Journal Article ]
  2. Singh SR, Zhen W, Zheng Z, Wang H, Oh SW, Liu W, Zbar B, Schmidt LS, Hou SX.
    Oncogene. 25: 5933-41, 2006. [ Journal Article ]
  3. Wang H, Singh SR, Zheng Z, Oh SW, Chen X, Edwards K, Hou SX.
    Dev. Cell. 10: 117-26, 2006. [ Journal Article ]
  4. Singh SR, Zeng X, Zheng Z, Hou SX.
    Cell Cycle. 10: 1109-20, 2011. [ Journal Article ]
  5. Singh SR, Mishra MK, Kango-Singh M, Hou SX.
    Methods Mol. Biol.. 879: 47-69, 2012. [ Journal Article ]

Biography

Dr. Shree Ram Singh obtained his Ph.D. in genetics from Department of Zoology, Banaras Hindu University, India in 2001. He was guest scientist at the Department of Molecular Cell Biology, Biocenter, Johann Wolfgang Goethe University Frankfurt, Germany in 1998 and in a UNESCO-BAC fellowship at the Department of Plant Molecular Biology Biocenter, Johann Wolfgang Goethe University Frankfurt, Germany in 2001. He pursued Post-doctoral research studies at University of Haifa, Israel and at National Cancer Institute at Frederick. Since 2011, he is a Staff Scientist at National Cancer Institute at Frederick.