Shannon M. Doyle, Ph.D.
Staff Scientist

The Wickner lab is focused on understanding the mechanisms of ATP dependent molecular chaperones. One specific aim is to understand the role of the molecular chaperone ClpB in protein disaggregation and remodeling. We are interested in determining the biochemical mechanism of action for ClpB as well as understanding how ClpB collaborates with other chaperones, such as DnaK, in protein disaggregation.

Areas of Expertise
molecular chaperones

Contact Info

Shannon M. Doyle, Ph.D.

Center for Cancer Research
National Cancer Institute

Building 37, Room 5144
Bethesda, MD 20892-4263
301-402-9282

The Wickner lab is focused on understanding the mechanisms of ATP dependent molecular chaperones. One specific aim is to understand the role of the molecular chaperone ClpB in protein disaggregation and remodeling. We are interested in determining the biochemical mechanism of action for ClpB as well as understanding how ClpB collaborates with other chaperones, such as DnaK, in protein disaggregation.

Selected Publications
  1. Doyle SM, Genest O, Wickner S.
    Nat. Rev. Mol. Cell Biol.. 14: 617-29, 2013. [ Journal Article ]
  2. Doyle SM, Hoskins JR, Wickner S.
    J. Biol. Chem.. 287: 28470-9, 2012. [ Journal Article ]
  3. Zhang T, Ploetz EA, Nagy M, Doyle SM, Wickner S, Smith PE, Zolkiewski M.
    Proteins. 80: 2758-68, 2012. [ Journal Article ]
  4. Evans ML, Schmidt JC, Ilbert M, Doyle SM, Quan S, Bardwell JC, Jakob U, Wickner S, Chapman MR.
    Prion. 5: 2011. [ Journal Article ]
  5. Genest O, Hoskins JR, Camberg JL, Doyle SM, Wickner S.
    Proceedings of the National Academy of Sciences of the United States of America. 2011. [ Journal Article ]

Shannon Doyle did her undergraduate work in Microbiology at Michigan State University. She completed her Ph.D. in Biochemistry at the University of Connecticut in the lab of Dr. Carolyn M. Teschke. She continued as a postdoctoral fellow and then research fellow with Dr. Sue Wickner in the Laboratory of Molecular Biology in the National Cancer Institute prior to becoming the lab staff scientist.

Research

The Wickner lab is focused on understanding the mechanisms of ATP dependent molecular chaperones. One specific aim is to understand the role of the molecular chaperone ClpB in protein disaggregation and remodeling. We are interested in determining the biochemical mechanism of action for ClpB as well as understanding how ClpB collaborates with other chaperones, such as DnaK, in protein disaggregation.

Publications

Selected Publications
  1. Doyle SM, Genest O, Wickner S.
    Nat. Rev. Mol. Cell Biol.. 14: 617-29, 2013. [ Journal Article ]
  2. Doyle SM, Hoskins JR, Wickner S.
    J. Biol. Chem.. 287: 28470-9, 2012. [ Journal Article ]
  3. Zhang T, Ploetz EA, Nagy M, Doyle SM, Wickner S, Smith PE, Zolkiewski M.
    Proteins. 80: 2758-68, 2012. [ Journal Article ]
  4. Evans ML, Schmidt JC, Ilbert M, Doyle SM, Quan S, Bardwell JC, Jakob U, Wickner S, Chapman MR.
    Prion. 5: 2011. [ Journal Article ]
  5. Genest O, Hoskins JR, Camberg JL, Doyle SM, Wickner S.
    Proceedings of the National Academy of Sciences of the United States of America. 2011. [ Journal Article ]

Biography

Shannon Doyle did her undergraduate work in Microbiology at Michigan State University. She completed her Ph.D. in Biochemistry at the University of Connecticut in the lab of Dr. Carolyn M. Teschke. She continued as a postdoctoral fellow and then research fellow with Dr. Sue Wickner in the Laboratory of Molecular Biology in the National Cancer Institute prior to becoming the lab staff scientist.