Ruibai Luo, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 2042
- Bethesda, MD 20892
- 240-760-7475
- luoru@mail.nih.gov
RESEARCH SUMMARY
Dr. Luo's current research interests include: kinetics studies of Arf-Arf GAP interactions leading to GTP hydrolysis; structural analysis of the interface of Arf-Arf GAP; and Arf GAP functions in membrane trafficking and remodeling of cytoskeleton.Areas of Expertise
Kinetic Studies
Ruibai Luo, Ph.D.
Research
Dr. Luo's current research interests include: kinetics studies of Arf-Arf GAP interactions leading to GTP hydrolysis; structural analysis of the interface of Arf-Arf GAP; and Arf GAP functions in membrane trafficking and remodeling of cytoskeleton.
Publications
Selected Publications
Kinetic analysis of Arf GAP1 indicates a regulatory role for coatomer
J. Biol. Chem..
283:
21965-77,
2008.
[ Journal Article ]
Arf GAP2 is positively regulated by coatomer and cargo
Cell. Signal..
21:
1169-79,
2009.
[ Journal Article ]
GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity
J. Biol. Chem..
287:
17176-85,
2012.
[ Journal Article ]
Mutational analysis of the Arf1*GTP/Arf GAP interface reveals an Arf1 mutant that selectively affects the Arf GAP ASAP1
Curr. Biol..
15:
2164-9,
2005.
[ Journal Article ]
Kinetic analysis of GTP hydrolysis catalysed by the Arf1-GTP-ASAP1 complex
Biochem. J..
402:
439-47,
2007.
[ Journal Article ]
Biography
Staff Scientist
Ruibai Luo, Ph.D.
Dr. Luo received both her bachelor and master's degree in biochemistry and molecular biology from Wuhan University, Wuhan, China. She received her Ph.D. in biology in 2000 at the Graduate School and University Center of the City University of New York. She joined Dr. Paul Randazzo's lab as postdoctoral fellow in 2004 and was appointed staff scientist in the Laboratory of Cellular Molecular Biology in 2009.