Philip J. Lucas, Ph.D.
Philip J. Lucas, Ph.D.
Staff Scientist

My major research interest is understanding T cell homeostasis and the signals involved in communicating peripheral T cells status to the thymus. It is well known that the number and type of T cell is tightly regulated through a complex network of chemokines, hormones, cytokines and cell-cell interactions. Disruption of T cell homeostasis by altering T cell numbers in the peripheral immune system has been a useful tool in understanding the multitude of signals involved in peripheral T cell homeostasis. We are using similar methods to identify which of these signals are necessary to modify T cell output from the thymus.

Areas of Expertise
T cell, thymus

Contact Info

Philip J. Lucas, Ph.D.
Center for Cancer Research
National Cancer Institute
Bldg. 10, CRC Room 3-3288
Bethesda, MD 20892-1203
301-435-3542
lucasp@mail.nih.gov

My major research interest is understanding T cell homeostasis and the signals involved in communicating peripheral T cells status to the thymus. It is well known that the number and type of T cell is tightly regulated through a complex network of chemokines, hormones, cytokines and cell-cell interactions. Disruption of T cell homeostasis by altering T cell numbers in the peripheral immune system has been a useful tool in understanding the multitude of signals involved in peripheral T cell homeostasis. We are using similar methods to identify which of these signals are necessary to modify T cell output from the thymus.

Selected Publications
  1. El-Kassar N, Flomerfelt FA, Choudhury B, Hugar LA, Chua KS, Kapoor V, Lucas PJ, Gress RE.
    Int. Immunol.. 24: 661-71, 2012. [ Journal Article ]
  2. Kim GY, Ligons DL, Hong C, Luckey MA, Keller HR, Tai X, Lucas PJ, Gress RE, Park J.
    J Immunol. 188: 5859-66, 2012. [ Journal Article ]
  3. Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D.
    J. Immunol.. 188: 4866-75, 2012. [ Journal Article ]

BS,The Pennsylvania State University 1982 Microbiology and Molecular Biology PhD, The George Washington University 1991 Microbiology and Immunology Fellow, Washington University, Saint Louis, MO 1991 Mentor Dr. Dennis Loh Fellow, NIH, Experimental Immunology Branch 1995 Mentor Dr. Ronald Gress Staff Scientist, NIH, Experimental Transpl & Immunology Branch 2000

Research

My major research interest is understanding T cell homeostasis and the signals involved in communicating peripheral T cells status to the thymus. It is well known that the number and type of T cell is tightly regulated through a complex network of chemokines, hormones, cytokines and cell-cell interactions. Disruption of T cell homeostasis by altering T cell numbers in the peripheral immune system has been a useful tool in understanding the multitude of signals involved in peripheral T cell homeostasis. We are using similar methods to identify which of these signals are necessary to modify T cell output from the thymus.

Publications

Selected Publications
  1. El-Kassar N, Flomerfelt FA, Choudhury B, Hugar LA, Chua KS, Kapoor V, Lucas PJ, Gress RE.
    Int. Immunol.. 24: 661-71, 2012. [ Journal Article ]
  2. Kim GY, Ligons DL, Hong C, Luckey MA, Keller HR, Tai X, Lucas PJ, Gress RE, Park J.
    J Immunol. 188: 5859-66, 2012. [ Journal Article ]
  3. Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D.
    J. Immunol.. 188: 4866-75, 2012. [ Journal Article ]

Biography

BS,The Pennsylvania State University 1982 Microbiology and Molecular Biology PhD, The George Washington University 1991 Microbiology and Immunology Fellow, Washington University, Saint Louis, MO 1991 Mentor Dr. Dennis Loh Fellow, NIH, Experimental Immunology Branch 1995 Mentor Dr. Ronald Gress Staff Scientist, NIH, Experimental Transpl & Immunology Branch 2000