Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design

Basket of apples

The apple does not fall far from the tree. In this issue, Tran et al. describe synthetic small molecules that activate the ZTP riboswitch, a bacterial RNA that regulates gene expression. The apples signify RNA bound to particular synthetic ligands, with the best ligand being grasped by the researcher.

Lab/Branch/Program: 
Chemical Biology Laboratory
Citation: 

Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design
Brandon Tran, Patricio Pichling, Logan Tenney, Colleen M. Connelly, Michelle H. Moon, Adrian R. Ferre´-D’Amare´ ,
John S. Schneekloth, Jr.* and Christopher P. Jones* in Cell Chemical Biology, 202027, 1241–1249

Published Date: 
October, 2020