The apple does not fall far from the tree. In this issue, Tran et al. describe synthetic small molecules that activate the ZTP riboswitch, a bacterial RNA that regulates gene expression. The apples signify RNA bound to particular synthetic ligands, with the best ligand being grasped by the researcher.
Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design
Brandon Tran, Patricio Pichling, Logan Tenney, Colleen M. Connelly, Michelle H. Moon, Adrian R. Ferre´-D’Amare´ ,
John S. Schneekloth, Jr.* and Christopher P. Jones* in Cell Chemical Biology, 2020, 27, 1241–1249