Clinical studies taking place at the NIH Clinical Center led by MMP investigators are presented below. To search for additional myeloid malignancies clinical trials, please visit clinicaltrials.gov.
Current Trials
Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult MDS (Open - Recruiting)
ID: NCT05350748
Investigator: Kathy McGraw, Ph.D.
Contact: Christine McGowan (240) 474-3584
A Phase I/II Trial of BMS-986253 in Myelodysplastic Syndromes (Open - Recruiting)
ID: NCT05148234
Investigator: Steven Z Pavletic, M.D., PhD.
Contact: Christine McGowan (240) 474-3584
Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples From Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies (Open - Recruiting)
ID: NCT05588154
Investigator: Kathy McGraw, Ph.D.
Contact: Christine McGowan (240) 474-3584
Front Line Ibrutinib for Newly Diagnosed Chronic Graft-Versus Host Disease (Open - Recruiting)
ID: NCT04294641
Investigator: Steven Z Pavletic, M.D., PhD.
Contact: Steven Z Pavletic, M.D., PhD. (240) 760-6174
Natural History of Acquired and Inherited Bone Marrow Failure Syndromes (Open - Recruiting)
ID: NCT05012111
Investigator: Emma M. Groarke, M.D.
Contact: Katherine C. Roskom, R.N. (301) 451-7094
Optimizing PTCy Dose and Timing (Open - Recruiting)
ID: NCT03983850
Investigator: Christopher G. Kanakry, M.D.
Contact: Amy H. Chai (240) 858-3755
Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies (Open - Recruiting)
ID: NCT04959175
Investigator: Christopher G. Kanakry, M.D.
Contact: Jennifer L. Sadler (240) 760-6172
CHIP/CCUS Natural History Protocol (Open - Recruiting)
ID: NCT04102423
Investigator: Emma M. Groarke, M.D.
Contact: Ivana Darden, R.N. (301) 827-2988
Longitudinal Studies of Patient With FPDMM (Open - Recruiting)
ID: NCT03854318
Investigator: Paul Liu, M.D.
Contact: Natalie T. Deuitch (301) 385-5205
A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome (Open - Recruiting)
ID: NCT05027945
Investigator: Dennis Hickstein, M.D.
Contact: Dennis D Hickstein, M.D. (240) 760-6169
Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations (Open - Recruiting)
ID: NCT01861106
Investigator: Dennis Hickstein, M.D.
Contact: Dennis D Hickstein, M.D. (240) 760-6169
Phase 1/2 Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid Leukemia (Open - Recruiting)
Investigator: Nirali Shah, M.D.
ID: NCT03971799
Contact: Hati Kobusingye (763) 406-4385
Contact: Erin Leckrone (763) 406-5124
Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation (Open - Recruiting)
Investigator: Steven Pavletic, PhD, M.D.
ID: NCT02356159
Contact: Ashley E Carpenter (240) 858-3190
Contact: Steven Z Pavletic, M.D., PhD. (240) 760-6174
Phase I/II Trial of PLX3397 in Children and Young Adults with Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) (Open - Recruiting)
ID: NCT02390752
Investigator: Rosandra Kaplan, M.D.
Contact: Elaine W. Thomas (240) 858-7013
Contact: Rosandra N Kaplan, M.D. (240) 760-6198
Cancer in Inherited Bone Marrow Failure Syndromes (Open - Recruiting)
ID: NCT00027274
Investigator: Neelam Giri, M.D.
Contact: Ann Carr (800) 518-8474
Contact: Neelam Giri, M.D. (240) 276-7256
Natural History Study of GATA2 Deficiency and Related Disorders (Open - Recruiting)
ID: NCT01905826
Investigator: Steven M Holland, M.D.
Contact: Merertu Tesso (301) 402-7831
Contact: Steven M Holland, M.D. (301) 402-7684
A First-In-Human, Open-Label, Multicenter Study of VOR33 in Patients with Acute Myeloid Leukemia who are at High-Risk for Leukemia Relapse following Hematopoietic Cell Transplantation(Open - Recruiting)
ID: NCT04849910
Investigator: Nirali Shah, M.D., MHSc
Contact: Nirali N. Shah, MD, MHSc (240) 760-6199
Eltanexor (KPT-8602) With Inqovi (Decitabine-Cedazuridine) in High-Risk Myelodysplastic Syndromes (Open - Recruiting)
ID: NCT05918055
Investigator: Steven Z Pavletic, M.D., PhD.
Contact: Ashley E Carpenter (240) 858-3190
To search additional myeloid malignancies clinical trials, please visit clinicaltrials.gov.